Relationship of the lung microbiome with PD-L1 expression and immunotherapy response in lung cancer

Respiratory Research

Yeon Wook Kim¹  Young-Jae Cho¹  Song Yee Kim²  Hye Jin Jang²  Young Sam Kim²  Moo Suk Park²  Ji Yeon Choi²  Ji Ye Jung²  Kangjoon Kim²  Sang Hoon Lee²  Seung Hyun Yong²  Young Ae Kang²  Eun Young Kim² 

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, 463-707, Seongnam-si, Gyeonggi-do, Republic of Korea;Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Republic of Korea;

关键词: Human microbiome;    Taxonomy;    Lung cancer;    PD-L1 expression levels;   

DOI  :  10.1186/s12931-021-01919-1

来源: Springer

【 摘 要 】

BackgroundLung cancer is the primary cause of cancer-related deaths worldwide. The human lung serves as a niche to a unique and dynamic bacterial community that is related to the development of multiple diseases. Here, we investigated the differences in the lung microbiomes of patients with lung cancer.Methods16S rRNA sequencing was performed to evaluate the respiratory tract microbiome present in the bronchoalveolar lavage fluid. Patients were stratified based on programmed death-ligand 1 (PD-L1) expression levels and immunotherapy responses.ResultsIn total, 84 patients were prospectively analyzed, of which 59 showed low (< 10%), and 25 showed high (≥ 10%) PD-L1 expression levels. The alpha and beta diversities did not significantly differ between the two groups. Veillonella dispar was dominant in the high-PD-L1 group; the population of Neisseria was significantly higher in the low-PD-L1 group than in the high-PD-L1 group. In the immunotherapy responder group, V. dispar was dominant, while Haemophilus influenzae and Neisseria perflava were dominant in the non-responder group.ConclusionThe abundances of Neisseria and V. dispar differed significantly in relation to PD-L1 expression levels and immunotherapy responses.

【 授权许可】

CC BY