Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

Nano-Micro Letters

Guosong Hong¹  Yu Shrike Zhang²  Yulong Han³  Xingcai Zhang³  Yiwei Li³  Ming Guo⁴  Xing Chen⁵  Xuechun Ren⁶  Xiaoqing Guo⁶  Shuojia Chen⁶  Ying Wang⁶  Ting Chen⁶  Zhongmin Tian⁶  Di Gao⁶  Hao Wang⁶  Zhe Yang⁶ 

[1] Department of Materials Science and Engineering, Stanford University, 94305, Stanford, CA, USA;Division of Engineering in Medicine, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, 02139, Cambridge, MA, USA;Paulson School of Engineering and Applied Sciences, John A, Harvard University, 02138, Cambridge, MA, USA;School of Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA;School of Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA;School of Public Health, Guangxi Medical University, 530000, Nanning, People’s Republic of China;The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, 710049, Xi’an, People’s Republic of China;

关键词: Photothermal therapy (PTT);    Thermodynamic therapy (TDT);    Targeting hybrid nanobullet;    Hypoxia tumor;    Zinc phthalocyanine aggregate (ZPA);   

DOI  :  10.1007/s40820-021-00616-4

来源: Springer

【 摘 要 】

tsAn all-organic hybrid nanobullets labeled as ZPA@HA-ACVA-AZ NBs was developed for the “precise strike”of hypoxic tumors through an oxygen-independently synergistic PTT/TDT, possessing therapeutic advantages over traditional ROS-mediated cancer treatment.By feat of dual-targeting effect from surface-modified HA (targeting CD44 receptors) and AZ (targeting CA IX), the nanobullets accumulated at hypoxic tumors efficiently.The synergism of intelligent nanobullets could suppress the primary breast tumor growth and lung metastasis via CA IX inhibition by AZ and synergistic PTT/TDT.

【 授权许可】

CC BY