Higher body mass index indicated better overall survival in pancreatic ductal adenocarcinoma patients: a real-world study of 2010 patients

BMC Cancer

Baiyong Shen¹  Xiaxing Deng¹  Yu Jiang¹  Hao Chen¹  Ningzhen Fu¹  Kai Qin¹ 

[1] Department of General Surgery, Pancreatic Disease Center, Shanghai Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, No.197 Ruijin Er Road, 200025, Shanghai, China;Research Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, No.197 Ruijin Er Road, 200025, Shanghai, China;State Key Laboratory of Oncogenes and Related Genes, No.197 Ruijin Er Road, 200025, Shanghai, China;Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, China;

关键词: Body mass index (BMI). Pancreatic ductal adenocarcinoma (PDAC). Overall survival (OS). Restricted cubic spline (RCS). Chemotherapy;   

DOI  :  10.1186/s12885-021-09056-0

来源: Springer

【 摘 要 】

BackgroundThe association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear,MethodA total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses.ResultBMI was linearly related to the OS (total P = 0.004, nonlinear P = 0.124). BMI was analyzed as categorical data based on X-tile software-defined cutoffs and World Health Organization (WHO)-recommended cutoffs. Adjusted with confounding covariates, higher BMI manifested as a positive prognostic predictor. Furthermore, BMI was proven to be associated with the OS in the PS analysis. (UnderweightXtile vs. NormalXtileP = 0.003, OverweightXtile vs. NormalXtileP = 0.019; UnderweightWHO vs. NormalWHOP < 0.001, OverweightWHO vs. NormalWHOP = 0.024). It was also revealed that patients with higher BMI benefitted more from chemotherapy. (Adjusted hazard ratio (aHR): UnderweightXtile vs. NormalXtile vs. OverweightXtile: 0.565 vs. 0.474 vs. 0.409; UnderweightWHO vs. NormalWHO vs. OverweightWHO: 0.613 vs. 0.464 vs. 0.425).ConclusionAmong PDAC patients, there was a positive association between BMI and the OS, especially in patients treated with chemotherapy.

【 授权许可】

CC BY