Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers

Nano-Micro Letters

Wei Huang¹  Deyue Yan¹  Xiaoyuan Yang¹  Xuelin Xia¹  Xiaoxia Xia² 

[1] School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 200240, Shanghai, People’s Republic of China;State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240, Shanghai, People’s Republic of China;

关键词: Molecular self-assembly;    Affibody-drug conjugate;    Nanoagent;    Targeted cancer therapy;   

DOI  :  10.1007/s40820-021-00762-9

来源: Springer

【 摘 要 】

tsThe nanoagent of affibody-drug conjugate made of ZHER2:342 and MMAE was successfully fabricated through molecular self-assembly of the conjugate in aqueous solution for targeted cancer therapy, which is recorded as Z-M ADCN for short.Z-M ADCN shows extraordinary anticancer ability in HER2-positive ovary and breast tumor models with good biosecurity, that nearly eradicated both small solid tumors (about 100  mm3) and large tumors (exceed 500  mm3).

【 授权许可】

CC BY