期刊论文详细信息
Nano-Micro Letters | |
Self-Assembled Nanomicelles of Affibody-Drug Conjugate with Excellent Therapeutic Property to Cure Ovary and Breast Cancers | |
Wei Huang1  Deyue Yan1  Xiaoyuan Yang1  Xuelin Xia1  Xiaoxia Xia2  | |
[1] School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 200240, Shanghai, People’s Republic of China;State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240, Shanghai, People’s Republic of China; | |
关键词: Molecular self-assembly; Affibody-drug conjugate; Nanoagent; Targeted cancer therapy; | |
DOI : 10.1007/s40820-021-00762-9 | |
来源: Springer | |
【 摘 要 】
tsThe nanoagent of affibody-drug conjugate made of ZHER2:342 and MMAE was successfully fabricated through molecular self-assembly of the conjugate in aqueous solution for targeted cancer therapy, which is recorded as Z-M ADCN for short.Z-M ADCN shows extraordinary anticancer ability in HER2-positive ovary and breast tumor models with good biosecurity, that nearly eradicated both small solid tumors (about 100 mm3) and large tumors (exceed 500 mm3).
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO202203043545365ZK.pdf | 3258KB | download |