A case of Podocytic Infolding Glomerulopathy with SLE and literature review

BMC Nephrology

Chunli Cui¹  Yuting Liu¹  Chen Yu¹  Kun Zhang¹  Jieli Huang¹  Xi Liu¹  Yangyang Niu¹ 

[1] The Department of Nephrology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China;

关键词: Podocytic infolding glomerulopathy;    Podocytes,Systemic lupus erythematosus;    EB virus;    Ovarian tumor;   

DOI  :  10.1186/s12882-021-02615-4

来源: Springer

【 摘 要 】

BackgroundPodocytic infolding glomerulopathy (PIG) is a rare pathological change which was characterized by the microspheres or microtubular structures in the thickened glomerular basement membrane (GBM). Only a few dozen cases have been reported worldwide so far. Here we present a case of PIG with systemic lupus erythematosus.Case presentationA 61-year-old Chinese female was diagnosed with systemic lupus erythematosus with clinical manifestations of proteinuria, pleural effusion, seroperitoneum, anemia, leukopenia, thrombocytopenia, antinuclear antibody positive, and hypocomplementemia. She also had benign ovarian tumor and Epstein-Barr virus infection. Renal biopsy immunofluorescent staining showed IgM and C3 were granularly deposited along the capillary wall instead of typical “full house” features. Electron microscopy showed lots of microspheres structures were seen in the thickened GBM.ConclusionWe present a case of PIG in a patient with systemic lupus erythematosus. The mechanisms of PIG are unknown, but may be associated with connective tissue disease and podocyte injury.

【 授权许可】

CC BY