Contrasting compositions of sitting, standing, stepping, and sleeping time: associations with glycaemic outcome by diabetes risk

International Journal of Behavioral Nutrition and Physical Activity

Parneet Sethi¹  Neville Owen²  Christian J. Brakenridge³  David W. Dunstan³  Agus Salim⁴  John Bellettiere⁵  Alison Carver⁶  Sebastien F. M. Chastin⁷  Genevieve N. Healy⁸ 

[1] Baker Heart and Diabetes Institute, 99 Commercial Rd, 3004, Melbourne, VIC, Australia;Baker Heart and Diabetes Institute, 99 Commercial Rd, 3004, Melbourne, VIC, Australia;Centre for Urban Transitions, Swinburne University of Technology, Melbourne, VIC, Australia;Baker Heart and Diabetes Institute, 99 Commercial Rd, 3004, Melbourne, VIC, Australia;Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia;Baker Heart and Diabetes Institute, 99 Commercial Rd, 3004, Melbourne, VIC, Australia;School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia;Herbert Wertheim School of Public Health and Longevity Science, University of California San Diego, La Jolla, CA, USA;Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia;School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK;Department of Movement and Sports Science, Ghent University, Ghent, Belgium;School of Public Health, The University of Queensland, Brisbane, QLD, Australia;

关键词: Time-use;    Diabetes risk;    Glycaemic control;    Sedentary behaviour;   

DOI  :  10.1186/s12966-021-01209-5

来源: Springer

【 摘 要 】

BackgroundRecent evidence suggests that prolonged sitting and its adverse impact on glycaemic indicators appear to be proportional to the degree of insulin resistance. To investigate this finding in a free-living context, we aimed to examine associations of device-measured 24-h time-use compositions of sitting, standing, stepping, and sleeping with fasting glucose (FPG) and 2 h post-load glucose (2hPLG) levels, and to examine separately the associations with time-use compositions among those at lower and at higher risk of developing type 2 diabetes.MethodsCross-sectional analyses examined thigh-worn inclinometer data (activPAL, 7 day, 24 h/day protocol) from 648 participants (aged 36-80 years) at either lower (< 39 mmol/mol; < 5.7% HbA1c) or higher (≥39 mmol/mol; ≥5.7% HbA1c) diabetes risk from the 2011-2012 Australian Diabetes, Obesity and Lifestyle study. Multiple linear regression models were used to examine associations of differing compositions with FPG and 2hPLG, with time spent in each behaviour allowed to vary up to 60 min.ResultsIn general, the associations with the FPG within the time-use compositions were small, with statistically significant associations observed for sitting and sleeping (in the lower diabetes risk group) and standing (in higher diabetes risk group) only. For 2hPLG, statistically significant associations were observed for stepping only, with findings similar between lower (β = − 0.12 95%CI:−0.22, − 0.02) and higher (β = − 0.13 95%CI:−0.26, − 0.01) risk groups. Varying the composition had minimal impact on FPG; however 1 h less sitting time and equivalent increase in standing time was associated with attenuated FPG levels in higher risk only (Δ FPG% = − 1.5 95%CI: − 2.4, − 0.5). Large differences in 2hPLG were observed for both groups when varying the composition. One hour less sitting with equivalent increase in stepping was associated with attenuated 2hPLG, with estimations similar in lower (Δ 2hPLG% = − 3.8 95%CI: − 7.3, − 0.2) and higher (Δ 2hPLG% = − 5.0 95%CI: − 9.7, − 0.0) risk for diabetes.ConclusionsIn middle-aged and older adults, glycaemic control could be improved by reducing daily sitting time and replacing it with stepping. Standing could also be beneficial for those at higher risk of developing type 2 diabetes.

【 授权许可】

CC BY