Factors associated with prolonged duration of viral clearance in non-severe SARS-CoV-2 patients in Osaka, Japan

Environmental Health and Preventive Medicine

Yasushi Mori¹  Satomi Fujita¹  Rumiko Asada¹  Toshitake Ohara¹  Jun Masui¹  Ayumi Murayama¹  Takanori Hirayama¹  Haruna Kawachi²  Emma Nakagawa Hoffman²  Atsushi Hirayama²  Jingwen Zhang²  Hiroyasu Iso³ 

[1] Osaka Prefectural Government, Department of Public Health and Medical Affairs, 1-2 Otemae, Chuo-ku, 540-8570, Osaka, Japan;Osaka Prefectural Government, Department of Public Health and Medical Affairs, 1-2 Otemae, Chuo-ku, 540-8570, Osaka, Japan;Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita City, 565-0871, Osaka, Japan;Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita City, 565-0871, Osaka, Japan;

关键词: COVID-19;    Virus shedding;    Comorbidity;    Longitudinal studies;   

DOI  :  10.1186/s12199-021-01035-y

来源: Springer

【 摘 要 】

BackgroundWe investigated factors associated with prolonged viral clearance of SARS-CoV-2 among non-severe adult patients in Osaka, Japan. A total of 706 laboratory-confirmed COVID-19 patients were enrolled in this longitudinal observational study between 29 January 2020 and 31 May 2020, across 62 hospitals and three non-hospital recuperation facilities.MethodsLogistic regression analysis was performed to investigate the factors associated with prolonged (29 days: upper 25% in duration) viral clearance of SARS-CoV-2. Linear regression analysis was conducted to assess these factors 14 days after symptom onset.ResultsThe median duration of viral clearance was 22 days from symptom onset. After adjustment for sex, age, symptoms, comorbidity, and location of recuperation, comorbidities were associated with prolonged duration: (OR, 1.77 [95% CI, 1.11–2.82]) for one, (OR, 2.47 [95% CI, 1.32–4.61]) for two or more comorbidities. Viral clearance 14 days after symptom onset was 3 days longer for one comorbidity and 4 days longer for two or more comorbidities compared to clearance when there was no comorbidity.ConclusionThe presence of comorbidity was a robust factor associated with a longer duration of viral clearance, extending by 3 to 4 days compared to patients with no comorbidity.

【 授权许可】

CC BY