BMC Pediatrics | |
25-Hydroxyvitamin D levels among 2-year-old children: findings from the Japan environment and Children’s study (JECS) | |
Limin Yang1  Kazue Ishitsuka1  Yukihiro Ohya1  Hidetoshi Mezawa1  Kiwako Yamamoto-Hanada1  Mayako Saito-Abe1  Miori Sato1  Hatoko Sasaki1  Makoto Irahara1  Minaho Nishizato1  Mizuho Konishi1  | |
[1] Division of Allergy, Department of Medical Subspecialties, Medical Support Center for Japan Environment and Children’s Study (JECS), Allergy Center, National Center for Child Health and Development, 2-10-1, Okura, Setagayaku, 157-8535, Tokyo, Japan;Medical Support Center for the Japan Environment and Children’s Study, National Research Institute for Child Health and Development, Tokyo, Japan; | |
关键词: 25-Hydroxyvitamin D; Vitamin D; Deficiency; Insufficiency; Children; Cohort; | |
DOI : 10.1186/s12887-021-03005-3 | |
来源: Springer | |
【 摘 要 】
BackgroundThe study aim was to obtain epidemiological data on vitamin D levels for the pediatric population in Japan. We assessed the prevalence of vitamin D deficiency and insufficiency in 2-year-old Japanese children using data from a large ongoing birth cohort study.MethodsData for analysis was obtained from the Japan Environment and Children’s Study (JECS) and a Sub-Cohort Study (SCS) of JECS. We evaluated the children’s serum 25(OH) D levels by 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles, and the rates of vitamin D deficiency or insufficiency. We also presented a weighted prevalence rate for vitamin D deficiency or insufficiency among all children in JECS.ResultsAfter excluding children with missing 25(OH)D2 or 25(OH)D3 data, we analyzed 4655 remaining children, of whom 24.7% (95% CI, 23.5–26.0%) had vitamin D deficiency (< 20 ng/mL), and 51.3% (95% CI, 49.8–52.7%) were at risk of vitamin D insufficiency (20–30 ng/mL). The estimated prevalence of vitamin D deficiency and insufficiency among all children in JECS were 25.4% (95% CI, 24.1–26.7%) and 50.9% (95% CI, 49.4–52.4%). Vitamin D deficiency was found in 22.9% of boys and 26.5% of girls. Median serum 25(OH) D concentrations were lower among participants measured during winter and spring than among those measured in summer and autumn. The highest rate of vitamin D deficiency was observed in Hokkaido, the northernmost prefecture of Japan.ConclusionWe analyzed data on serum 25(OH) D levels from a birth cohort study and found that vitamin D deficiency and insufficiency are very common among 2-year-old Japanese children. Sex, season, and latitude affect serum 25(OH) D concentrations.
【 授权许可】
CC BY
【 预 览 】
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