Plasma atherogenic indices are independent predictors of slow coronary flow

BMC Cardiovascular Disorders

Ramazan Asoglu¹  Yusuf Hosoglu¹  Abdulmecit Afsin¹  Kader Eliz Uzel¹  Fethi Yavuz²  Hakan Kaya²  Arif Suner²  Nurbanu Bursa³ 

[1] Department of Cardiology, Adiyaman Training and Research Hospital, Adiyaman, Turkey;Department of Cardiology, Faculty of Medicine, Adiyaman University, Adiyaman, Turkey;Department of Statistics, Faculty of Science, Hacettepe University, Ankara, Turkey;

关键词: Coronary slow flow;    Frame count;    Atherogenic index of plasma;    Castelli risk indices;    Coronary intervention;    Cardiovascular risk factors;    Coronary artery;   

DOI  :  10.1186/s12872-021-02432-5

来源: Springer

【 摘 要 】

BackgroundAlthough the pathophysiology of coronary slow flow (CSF) has not been fully elucidated, emerging data increasingly support potential role for subclinical diffuse atherosclerosis in the etiology of CSF. We aimed to investigate relationship between atherogenic indices and CSF.Methods130 patients with CSF diagnosed according to Thrombolysis in Myocardial Infarction (TIMI)-frame count (TFC) method and 130 controls who had normal coronary flow (NCF) were included in this retrospective study. Atherogenic indices (atherogenic index of plasma [AIP], Castelli risk indices I and II [CRI-I and II]) were calculated using conventional lipid parameters.ResultsThe logistic regression analyses demonstrated that AIP (OR, 5.463; 95% confidence interval [CI], 1.357–21.991; p = 0.017) and CRI-II (OR, 1.624; 95% CI, 1.138–2.319; p = 0.008) were independent predictors of CSF. Receiver operating characteristic analysis showed that the optimal cutoff value to predict the occurrence of CSF was 0.66 for AIP (sensitivity, 59%; specificity, 73%; area under curve [AUC], 0.695; p < 0.001) and 3.27 for CRI-II (sensitivity, 60%; specificity, 79%; AUC, 0.726; p < 0.001).ConclusionsAIP and CRI-II levels were independent predictors of CSF. Prospective studies in larger cohorts of patients may elucidate the role of atherogenic dyslipidemia in the pathophysiology of CSF.

【 授权许可】

CC BY