Parsonage–Turner syndrome following coronavirus disease 2019 immunization with ChAdOx1-S vaccine: a case report and review of the literature

Journal of Medical Case Reports

Angelo Schenone¹  Marina Grandis¹  Bruno Kusznir Vitturi²  Giancarlo Icardi³  Paolo Durando⁴  Andrea Orsi⁵  Sabrina Beltramini⁶ 

[1] DINOGMI, University of Genoa, Genoa, Italy;Neurology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Department of Health Sciences, University of Genoa, L.go R. Benzi, 10 (Building 3), 16122, Genoa, Italy;Department of Health Sciences, University of Genoa, L.go R. Benzi, 10 (Building 3), 16122, Genoa, Italy;Hygiene Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Department of Health Sciences, University of Genoa, L.go R. Benzi, 10 (Building 3), 16122, Genoa, Italy;Occupational Medicine Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Hygiene Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy;Pharmacy Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy;

关键词: Acute brachial neuritis;    Adverse reactions;    COVID-19;    COVID-19 vaccines;    Neuralgic amyotrophy;    Parsonage–Turner syndrome;   

DOI  :  10.1186/s13256-021-03176-8

来源: Springer

【 摘 要 】

BackgroundParsonage–Turner syndrome is an acute peripheral neuropathy that affects the upper brachial plexus region. Previously published reports demonstrate that the condition can be triggered by surgery, infection, autoimmune diseases, strenuous exercise, trauma, radiation, and vaccination. Parsonage–Turner syndrome has already been reported in three other patients who were vaccinated against coronavirus disease 2019.Case presentationWe report the case of a 51-year-old Caucasian man without comorbidities who received the first dose of the ChAdOx1-S recombinant vaccine (Vaxzevria, AstraZeneca, Oxford, UK) against coronavirus disease 2019 and was diagnosed with Parsonage–Turner syndrome. A few days after getting vaccinated, the patient reported a progressive increase in pain in the region of vaccine administration. One month later, the shoulder pain was followed by symptoms of hypoesthesia and muscle weakness on abduction and elevation of the left upper limb. Neurological examination revealed an atrophy of the proximal muscles of the left upper limb, accompanied by paresis of the left deltoid, biceps brachii, triceps brachii, and infraspinatus muscles. Electroneuromyography carried out 3 months after the onset of symptoms showed signs consistent with brachial plexus neuritis. The adverse reaction has been properly reported to the Italian Pharmacovigilance System (Italian Medicines Agency—Agenzia Italiana del Farmaco.ConclusionThe increased awareness of such association is essential for early identification and diagnosis and, thus, better clinical outcomes.

【 授权许可】

CC BY