Simultaneous administration of coffee and rasagiline/l-dopa protects against paraquat-induced neurochemical and motor behavior impairments in vivo

Bulletin of the National Research Centre

Yousreya A. Maklad¹  Asmaa M. Salman¹  Mona E. Aboutabl¹  Amina A. Gamal el Din² 

[1] Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), P.O. 12622, 33 El Bohouth St., Dokki, Giza, Egypt;Pathology Department, Medical Research and Clinical Studies Institute, National Research Centre (ID: 60014618), P.O. 12622, 33 El Bohouth St., Dokki, Giza, Egypt;

关键词: Parkinson's disease;    Paraquat;    Coffee;    Rasagiline;    Caffeine;    Neurochemical disturbances;    Motor impairments;    Behavior tests;   

DOI  :  10.1186/s42269-021-00678-9

来源: Springer

【 摘 要 】

BackgroundCaffeine is a natural alkaloid present in a variety of highly consumed popular drinks such as coffee, tea and soft drinks as well as chocolate. Its consumption elicits beneficiary psychostimulant that has been linked to a reduced risk of developing Parkinson’s disease (PD). The aim of the present study is to investigate the possible synergistic neuroprotective effects of co-administration of caffeine (CAF) or coffee (COF) with rasagiline (R) or l-dopa against paraquat (PQ)-induced neurochemical and motor behavior impairments in mice.ResultsIn behavioral tests, R + COF increased the locomotor activity in rotarod test compared to l-dopa + COF. l-Dopa combinations decreased the immobility time in FST compared to rasagiline combinations; l-dopa + CAF provided a similar increase in locomotor activity compared to R + CAF. Combination of CAF or COF with l-dopa or rasagiline resulted in a substantial improvement in brain neurotransmitter and antioxidant levels as they significantly increased dopamine and super oxide dismutase but significantly decreased nitric oxide levels as compared to l-dopa or rasagiline, respectively. Furthermore, they also exerted a protective effect against the neurodegenerative histopathological changes induced by PQ.ConclusionsOur findings demonstrated co-administration of COF or CAF, adenosine 2A receptor antagonists, along with l-dopa or rasagiline possesses a new therapeutic strategy for the management of PD neurochemical disturbances and motor behavior impairments through preservation of the brain dopamine and serotonin content, antioxidants level and histological features.

【 授权许可】

CC BY