Association of circulating let-7b-5p with major depressive disorder: a nested case-control study

BMC Psychiatry

Sanne Roumans¹  Anna Hedelius¹  Ashfaque A. Memon¹  Xiao Wang²  Kristina Sundquist³  Jan Sundquist³ 

[1] Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden;Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden;Center for Primary Health Care Research, Wallenberg Laboratory, Inga-Marie Nilssons gata 53, plan 6 Box 50332, 202 13, Malmö, Sweden;Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden;Department of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA;Center for Community-based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine, Shimane University, Matsue, Japan;

关键词: Let-7b-5p;    Major depressive disorder;    MDD;    Depression;    miRNA;    Biomarker;    Risk prediction;   

DOI  :  10.1186/s12888-021-03621-4

来源: Springer

【 摘 要 】

BackgroundMajor depressive disorder (MDD) is one of the most common psychiatric disorders and is a great disease burden. However, its underlying pathophysiology and aetiology remain poorly understood. Available evidence suggests that circulating microRNAs (miRNAs) are associated with MDD, but it is still unknown whether miRNAs can predict subsequent incident MDD.MethodsIn this nested case-control study, a total of 104 individuals, who were free of MDD at baseline, from the Women’s Health in Lund Area (WHILA) cohort were included. Among them, 52 individuals developed MDD (cases) during the 5 years follow-up and 52 individuals did not develop MDD (controls). Plasma expression levels of miR-17-5p, miR-134-5p, miR-144-5p, let-7b-5p and let-7c-5p at baseline were assessed using qRT-PCR. Logistic regression was used to estimate the odds of developing MDD among individuals with different levels of miRNA expression.ResultsPlasma expression levels of let-7b-5p were significantly lower (p = 0.02) at baseline in cases compared to controls. After adjustment for age and BMI, let-7b-5p was negatively associated with odds for developing MDD (OR = 0.33, p = 0.03, 95% CI = 0.12–0.91). Moreover, let-7b-5p expression levels showed a trend over time with larger differences between cases and controls for the earlier cases (MDD diagnosis <2 years from baseline) than MDD cases developed later (MDD diagnosis 2–5 years from baseline).ConclusionsThese findings show that lower plasma levels of let-7b-5p are associated with a higher future risk of MDD. Results need to be validated in a large cohort to examine its potential as a peripheral biomarker for MDD.

【 授权许可】

CC BY