Non-obstructive idiopathic azoospermia vs azoospermia with antecedents of cryptorchidism: ways and probabilities of becoming parents

Basic and Clinical Andrology

Jean Marc Rigot¹  Romane Sainte Rose²  Laura Dijols²  Claire Petit²  Cynthia Frapsauce²  Jacques Singh Sangwan³  Fabrice Guérif⁴ 

[1] Department of Andrology and CECOS, Lille University Medical Centre, F-59000, Lille, France;Service de Médecine et Biologie de la Reproduction, Hôpital Bretonneau, F-37044, Tours, France;Service de Médecine et Biologie de la Reproduction, Hôpital Bretonneau, F-37044, Tours, France;Service de Gynécologie-Obstétrique, Hôpital Robert Debré, F-37400, Amboise, France;Service de Médecine et Biologie de la Reproduction, Hôpital Bretonneau, F-37044, Tours, France;Université François Rabelais, F-37041, Tours, France;INRAE, UMR85 PRC, CNRS, IFCE, F-37380, Nouzilly, France;

关键词: Non-obstructive azoospermia;    Cryptorchidism;    TESE-ICSI;    Sperm donation;    Embryo donation;    Azoospermie non-obstructive;    Cryptorchidie;    TESE-ICSI;    Don de sperme;    Don d’embryons;   

DOI  :  10.1186/s12610-021-00149-1

来源: Springer

【 摘 要 】

BackgroundNon-obstructive azoospermia (NOA) with history of cryptorchidism and idiopathic NOA are the most common forms of NOA without genetic aetiology. Of all patients with one of these two types of NOA, only a few will have a positive TEsticular Sperm Extraction (TESE). Of those with positive extraction followed by sperm freezing, not all will have a child after TESE-ICSI. What are the ways and probabilities of taking home a baby for patients with NOA and a history of cryptorchidism compared with patients with idiopathic NOA?ResultsPatients with idiopathic NOA or NOA and a history of cryptorchidism who underwent their first TESE were included. The patients were divided into two groups: Group 1 was composed of 125 patients with idiopathic NOA and Group 2 of 55 patients with NOA and a history of surgically treated cryptorchidism. Our results showed that more than half of the NOA patients succeeded in becoming parents. The main way to fulfil their plans for parenthood is to use sperm or embryo donation (72%) for men with idiopathic NOA, whereas the majority of men with NOA and a history of cryptorchidism had a child after TESE-ICSI (58.8%).ConclusionsIn our centre, before considering TESE for a patient with NOA, we explain systematically TESE-ICSI alternatives (sperm donation, embryo donation or adoption). As a result, the couple can consider each solution to become parents.

【 授权许可】

CC BY