Clinical factors associated with severe hypophosphataemia after kidney transplant

BMC Nephrology

Maximilian R. Ralston¹  Karen S. Stevenson¹  Colin C. Geddes¹  Patrick B. Mark² 

[1] Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, 1345 Govan Road, G51 4TF, Glasgow, UK;Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, 1345 Govan Road, G51 4TF, Glasgow, UK;Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK;

关键词: Kidney transplantation;    Hypophosphataemia;    Hyperparathyroidism;    Graft function;   

DOI  :  10.1186/s12882-021-02624-3

来源: Springer

【 摘 要 】

BackgroundThe mechanism by which hypophosphataemia develops following kidney transplantation remains debated, and limited research is available regarding risk factors. This study aimed to assess the association between recipient and donor variables, and the severity of post-transplantation hypophosphataemia.MethodsWe performed a single-centre retrospective observational study. We assessed the association between demographic, clinical and biochemical variables and the development of hypophosphataemia. We used linear regression analysis to assess association between these variables and phosphate nadir.Results87.6% of patients developed hypophosphataemia. Patients developing hypophosphataemia were younger, had a shorter time on renal replacement therapy, were less likely to have had a parathyroidectomy or to experience delayed graft function, were more likely to have received a living donor transplant, from a younger donor. They had higher pre-transplantation calcium levels, and lower alkaline phosphatase levels.Receipt of a living donor transplant, lower donor age, not having had a parathyroidectomy, receiving a transplant during the era of tacrolimus-based immunosuppression, not having delayed graft function, higher pre-transplantation calcium, and higher pre-transplantation phosphate were associated with lower phosphate nadir by multiple linear regression.ConclusionsThis analysis demonstrates an association between variables relating to better graft function and hypophosphataemia. The links with biochemical measures of mineral-bone disease remain less clear.

【 授权许可】

CC BY