Increased risk of Parkinson’s disease among patients with age-related macular degeneration

BMC Ophthalmology

Chih Sheng Chen¹  Po-Yu Jay Chen²  Peng-Tai Tien³  Jamie Jiin-Yi Chen⁴  Wu Ming Yen⁴  Hui-Ju Lin⁵  Kai-Chieh Hu⁶  Lu-Ting Chiu⁶  Jung-Nien Lai⁷  Lei Wan⁸ 

[1] Division of Chinese Medicine, Asia University Hospital, Taichung, Taiwan;Eye Center and Department of Molecular Genetics, China Medical University Hospital, Taichung, Taiwan;Eye Center and Department of Molecular Genetics, China Medical University Hospital, Taichung, Taiwan;Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan;School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;Department of Ophthalmology and Department of Molecular Genetics, China Medical University Hospital, Taichung, Taiwan;Eye Center and Department of Molecular Genetics, China Medical University Hospital, Taichung, Taiwan;School of Chinese Medicine, China Medical University, Taichung, Taiwan;Eye Center and Department of Molecular Genetics, China Medical University Hospital, Taichung, Taiwan;School of Chinese Medicine, China Medical University, Taichung, Taiwan;Department of Ophthalmology and Department of Molecular Genetics, China Medical University Hospital, Taichung, Taiwan;Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;School of Chinese Medicine, China Medical University, Taichung, Taiwan;School of Chinese Medicine, China Medical University, Taichung, Taiwan;Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan;Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan;

关键词: Parkinson’s disease (PD);    Age-related macular degeneration (AMD);    Retinal inflammation;   

DOI  :  10.1186/s12886-021-02196-8

来源: Springer

【 摘 要 】

BackgroundThis study aimed to investigate the risk of Parkinson’s disease (PD) among patients with age-related macular degeneration (AMD) and its association with confounding comorbidities.MethodsA population-based retrospective cohort study was conducted using Longitudinal Health Insurance Database 2000 (LHID2000). We established AMD and non-AMD cohorts from January 1, 2000 to December 31, 2012 to determine the diagnosis of PD. A total of 20,848 patients were enrolled, with 10,424 AMD patients and 10,424 controls matched for age, sex, and index year at a 1:1 ratio. The follow-up period was from the index date of AMD diagnosis to the diagnosis of PD, death, withdrawal from the insurance program, or end of 2013. Multivariable Cox regression analysis was performed to examine the hazard ratio (HR) and 95% confidence interval (CI) for the risk of PD between the AMD and non-AMD cohorts.ResultAfter adjusting for potential confounders, there was a higher risk of developing PD in the AMD cohort than in the non-AMD cohort (adjusted HR = 1.35, 95% CI = 1.16–1.58). A significant association could be observed in both female (aHR = 1.42, 95% CI = 1.13–1.80) and male (aHR = 1.28, 95% CI = 1.05–1.57) patients, aged more than 60 years (60–69: aHR = 1.51, 95% CI = 1.09–2.09, 70–79: aHR = 1.30, 95% CI = 1.05–1.60; 80–100: aHR = 1.40, 95% CI = 1.01–1.95), and with more than one comorbidity (aHR = 1.40, 95% CI = 1.20–1.64). A significant association between increased risk of PD and AMD was observed among patients with comorbidities of osteoporosis (aHR = 1.68, 95% CI = 1.22–2.33), diabetes (aHR = 1.41, 95% CI = 1.12–1.78) and hypertension (aHR = 1.36, 95% CI = 1.15–1.62) and medications of statin (aHR = 1.42, 95% CI = 1.19–1.69) and calcium channel blocker (CCB) (aHR = 1.32, 95% CI = 1.11–1.58). The cumulative incidence of PD was significantly higher over the 12-year follow-up period in AMD cohort (log-rank test, p < 0.001).ConclusionsPatients with AMD may exhibit a higher risk of PD than those without AMD.

【 授权许可】

CC BY