Rounded atelectasis after exposure to refractory ceramic fibres (RCF)

Particle and Fibre Toxicology

Marian Kampschulte¹  Anne S. Schulze²  Ulrike Brueckner²  Joachim Schneider²  Dirk Walter³ 

[1] Clinic for Diagnostic and Interventional Radiology, University Hospital, Justus-Liebig-University, Klinikstrasse 33, 35392, Giessen, Germany;Institute and Outpatient Clinic for Occupational and Social Medicine, Justus-Liebig-University, Aulweg 129, 35392, Giessen, Germany;Institute and Outpatient Clinic for Occupational and Social Medicine, Justus-Liebig-University, Aulweg 129, 35392, Giessen, Germany;Institute of Inorganic and Analytical Chemistry, Justus-Liebig-University, Heinrich-Buff-Ring 17, 35392, Giessen, Germany;

关键词: Aluminium silicate fibres;    RCF;    Thermal insulation;    Rounded atelectasis;    Restrictive lung function pattern;    Occupational diseases;   

DOI  :  10.1186/s12989-021-00441-y

来源: Springer

【 摘 要 】

BackgroundRefractory Ceramic fibres (RCF) are man-made mineral fibres used in high performance thermal insulation applications. Analogous to asbestos fibres, RCF are respirable, show a pleural drift and can persist in human lung tissue for more than 20 years after exposure. Pleural changes such as localised or diffuse pleural thickening as well as pleural calcification were reported.ResultA 45 years old man worked in high performance thermal insulation applications using refractory ceramic fibres (RCF) for almost 20 years. During a occupational medical prophylaxis to ensure early diagnosis of disorders caused by inhalation of aluminium silicate fibres with X-ray including high-resolution computed tomography (HRCT), bilateral pleural thickening was shown and a pleural calcification next to a rounded atelectasis was detected. Asbestos exposure could be excluded. In pulmonary function test a restrictive lung pattern could be revealed. In work samples scanning electron microscopy (SEM) including energy dispersive X-ray analysis (EDX) classified used fibres as aluminium silicate fibres. X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) showed crystalline as well as amorphous fibres.ConclusionsA comprehensive lung function analysis and in case of restrictive lung disorders additional CT scans are needed in RCF exposed workers in accordance to the guidelines for medical occupational examinations comparable to asbestos exposed workers.

【 授权许可】

CC BY