Analgesic, anti-inflammatory and acute oral toxicity profile of leaf and bark extracts of Albizia procera

BMC Complementary Medicine and Therapies

Sangeetha Mani¹  Chamundeeswari Duraipandian¹  Saravana Babu Chidambaram² 

[1] Dept of Pharmacognosy, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, 600116, Chennai, India;Dept of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, 570015, Mysuru, Karnataka, India;

关键词: Albizia procera;    Acute oral toxicity;    Formalin test;    Carrageenan;    Cotton pellet granuloma;    Herbal medicine;   

DOI  :  10.1186/s12906-021-03497-7

来源: Springer

【 摘 要 】

BackgroundPain and inflammation are associatory events in cancer, diabetes, cardiovascular diseases, arthritis and other chronic diseases. Corticosteroids, non-steroidal anti-inflammatory drugs exert potential side effects on long term use. This study was aimed to investigate the acute oral toxicity, anti-inflammatory and analgesic activities of leaf and bark extracts of Albizia procera in experimental animal models.MethodsEthyl acetate, ethanol, and hydroalcoholic extracts of Albizia procera (leaf and bark) were subjected for acute oral toxicity, anti-inflammatory and analgesic screening. Carrageenan and cotton pellet granuloma models were used to assess acute and chronic anti-inflammatory effects, respectively. Intraplanar formalin test was used to assess the analgesic activity.ResultsAll the extracts of Albizia procera were found to be well-tolerated up to 2000 mg/kg in female rats. Ethanolic leaf (ETLE) and bark (ETBE) of Albizia procera showed anti-inflammatory actions. But, only ETBE produced significant protection in chronic inflammation and analgesic activity.ConclusionIn summary, Albizia procera possess significant anti-inflammatory and analgesic properties. This study adds evidence on the traditional use of Albizia procera plant for treating painful inflammatory disorders.

【 授权许可】

CC BY