Effects of high-intensity interval training on blood lactate levels and cognition in healthy adults: protocol for systematic review and network meta-analyses

Systematic Reviews

Maria Carmela Tartaglia¹  Bhanu Sharma²  Robin Green³  Isis So⁴  Susan Marzolini⁵  Nithin Jacob⁵ 

[1] Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada;Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Kembril Research Institute, Toronto Western-University Health Network, Toronto, Ontario, Canada;KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada;Department of Medical Sciences, McMaster University, Toronto, Ontario, Canada;KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada;Department of Psychiatry, Division of Neurosciences and Clinical Translation, University of Toronto, Toronto, Ontario, Canada;KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada;Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada;KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada;Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada;

关键词: Blood lactate;    High-intensity interval training;    Cognition;    Exercise;   

DOI  :  10.1186/s13643-021-01874-4

来源: Springer

【 摘 要 】

BackgroundHigh-intensity interval training (HIIT) has shown to confer cognitive benefits in healthy adults, via a mechanism purportedly driven by the exercise metabolite lactate. However, our understanding of the exercise parameters (e.g., work interval duration, session volume, work-to-rest ratio) that evoke a peak blood lactate response in healthy adults is limited. Moreover, evidence relating HIIT-induced blood lactate and cognitive performance has yet to be reviewed and analyzed. The primary objective of this systematic review is to use network meta-analyses to compare the relative impact of different HIIT work-interval durations, session volumes, and work-to-rest ratios on post-exercise blood lactate response in healthy adults. The secondary objective is to determine the relationship between HIIT-induced blood lactate and acute post-HIIT cognitive performance.MethodsA systematic review is being conducted to identify studies measuring blood lactate response following one session of HIIT in healthy adults. The search was carried out in (1) MEDLINE, (2) EMBASE, (3) Cochrane Central Register of Controlled Trials, (4) Sport Discus, and (5) Cumulative Index to Nursing and Allied Health Literature Plus with Full Text (CINAHL+). After abstract and full-text screening, two reviewers will independently extract data on key outcomes variables and complete risk of bias assessment using the Cochrane Risk of Bias Tool and the Risk of Bias in Non-Randomized Studies of Interventions tool. Network meta-analyses will be used to generate estimates of the comparative effectiveness of blood lactate on cognitive outcomes using corresponding rankings for each work-interval duration, session volume, and work-to-rest ratio category. Where applicable, meta-regressions analyses will be performed to test the relationship between changes in the blood lactate and changes in cognitive performance. Analyses will be conducted using MetaInsight Software.DiscussionThis study will provide evidence on how to structure a HIIT protocol to elicit peak blood lactate response in healthy adults and will increase our understanding of the relationship between HIIT-induced blood lactate response and associated cognitive benefits.Systematic review registrationPROSPERO CRD42020204400

【 授权许可】

CC BY