Chinese expert recommendations on ketogenic diet therapy for super-refractory status epilepticus

Acta Epileptologica

Fang Fang¹  Qun Wang²  Juan Wang³  Lifei Yu⁴  Meiping Ding⁵  Jiwen Wang⁶  Jianxiang Liao⁷  Dezhi Cao⁷  Dan Sun⁸  Zengning Li⁹  Jiong Qin^1,10  Guang Yang^1,11  Shaoping Huang^1,12  Xin Tong^1,13  Rong Luo^1,13  Qianyun Cai^1,13  Hua Li^1,14 

[1] Department of Neurology, Beijing Children’s Hospital, Capital Medical University, 100045, Beijing, China;Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100070, Beijing, China;Department of Neurology, Children’s Hospital of Chongqing Medical University, 401122, Chongqing, China;Department of Neurology, Children’s Hospital of Fudan University, 200032, Shanghai, China;Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, 310009, Hangzhou, China;Department of Neurology, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, 200127, Shanghai, China;Department of Neurology, Shenzhen Children’s Hospital, 518035, Shenzhen, China;Department of Neurology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430015, Wuhan, China;Department of Nutrition, The First Hospital of Hebei Medical University, 050000, Shijiazhuang, China;Department of Pediatrics, Peking University People’s Hospital, 100044, Beijing, China;Department of Pediatrics, The First Medical Center, Chinese PLA General Hospital, 100036, Beijing, China;Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, 710004, Xi’an, China;Department of Pediatrics, West China Second University Hospital, Sichuan University, 610041, Chengdu, China;Epilepsy Center, Guangdong 999 Brain Hospital, 510510, Guangzhou, China;

关键词: Super-refractory status epilepticus;    Ketogenic diet;    Intensive care units;    Consensus;    China;   

DOI  :  10.1186/s42494-021-00078-6

来源: Springer

【 摘 要 】

Super-refractory status epilepticus (SRSE) is a serious and life-threatening neurological condition. Ketogenic diet (KD) is a diet characterized by high fat, low carbohydrate, and moderate protein. As KD shows effectiveness in controlling seizures in more than half of SRSE patients, it can be a treatment option for SRSE. Currently, KD treatment for SRSE is based on personal experience and observational evidence has been published. In the context of a lack of a validated guideline, we convened a multicenter expert panel within the China Association Against Epilepsy (CAAE) Ketogenic Diet Commission to work out the Chinese expert recommendations on KD for SRSE. We summarize and discuss the latest clinical practice of KD for SRSE in critical care settings. Recommendations are given on patient selection, the timing of KD, diet implementation, and follow-up. More research data are needed in this area to support better clinical practice.

【 授权许可】

CC BY