Cardiovascular Diabetology | |
Association of visceral adiposity index with incident nephropathy and retinopathy: a cohort study in the diabetic population | |
Lixin Tao1  Zhiwei Li1  Siqi Yu1  Jinqi Wang1  Yue Liu1  Zongkai Xu1  Xinlei Miao1  Xiangtong Liu1  Xiuhua Guo2  Zhiyuan Wu2  Jingbo Zhang3  Xiaoping Kang4  Wei Wang5  Xia Li6  | |
[1] Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, 100069, Beijing, China;Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No.10 Xitoutiao, Youanmen Street, 100069, Beijing, China;Centre for Precision Health, Edith Cowan University, Perth, Australia;Beijing Physical Examination Center, Beijing, China;Beijing Xiaotangshan Hospital, Beijing, China;Centre for Precision Health, Edith Cowan University, Perth, Australia;Department of Mathematics and Statistics, La Trobe University, Melbourne, Australia; | |
关键词: Visceral adiposity index; Abdominal obesity; Diabetic nephropathy; Diabetic retinopathy; | |
DOI : 10.1186/s12933-022-01464-1 | |
来源: Springer | |
【 摘 要 】
BackgroundThe association between visceral adiposity index (VAI) and diabetic complications has been reported in cross-sectional studies, while the effect of VAI on complication development remains unclear. This study aims to evaluate the longitudinal association of VAI and Chinese VAI (CVAI) with the incidence of diabetic nephropathy and retinopathy using a Chinese cohort.MethodsA total of 8 948 participants with type 2 diabetes from Beijing Health Management Cohort were enrolled during 2013–2014, and followed until December 31, 2019. Nephropathy was confirmed by urine albumin/creatinine ratio and estimated glomerular filtration rate; retinopathy was diagnosed using fundus photograph.ResultsThe mean (SD) age was 53.35 (14.66) years, and 6 154 (68.8%) were men. During a median follow-up of 4.82 years, 467 participants developed nephropathy and 90 participants developed retinopathy. One-SD increase in VAI and CVAI levels were significantly associated with an increased risk of nephropathy, and the adjusted hazard ratios (HR) were 1.127 (95% CI 1.050–1.210) and 1.165 (95% CI 1.003–1.353), respectively. On contrary, VAI and CVAI level were not associated with retinopathy after adjusting confounding factors.ConclusionVAI and CVAI are independently associated with the development of nephropathy, but not retinopathy in Chinese adults with diabetes.
【 授权许可】
CC BY
【 预 览 】
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