期刊论文详细信息
BMC Gastroenterology | |
Helicobacter pylori infection is not an independent risk factor of non-alcoholic fatty liver disease in China | |
Mengke Fan1  Rong Lin1  Yurui Zhang1  Weijun Wang1  Junchao Zeng2  Sanping Xu2  Rui Gong2  | |
[1]Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China | |
[2]Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China | |
关键词: H. pylori; NAFLD; Risk factor; Infection; Association; | |
DOI : 10.1186/s12876-022-02148-6 | |
来源: Springer | |
【 摘 要 】
BackgroundThe role of Helicobacter pylori (H. pylori) infection in the development of non-alcoholic fatty liver disease (NAFLD) remains controversial. The exact relationship requires further investigation. This study aimed to determine the association between them in China.MethodsA retrospective study was conducted on 71,633 participants who underwent physical examinations. 13C urea breath test (13C-UBT) was conducted to detect H. pylori infection, and ultrasonography was used to detect NAFLD.ResultsBody mass index (BMI), blood pressure (BP), and triglyceride (TG) levels were higher in participants with H. pylori infection than in those without H. pylori infection. While the levels of high-density lipoprotein cholesterol (HDL-C) for participants with H. pylori infection was lower than without H. pylori infection (P < 0.001). After adjusting for confounding factors (age, sex, BMI, BP, Scr, BUN, LDL-C, HDL-C, triglycerides, FBG and HbA1c), multivariate logistic regression analysis indicated that there was no independent relationship between them (P = 0.574). Subgroup analysis (stratified by sex, age, BMI, hypertension, diabetes and dyslipidemia) showed that H. pylori infection was not included as an independent risk factor for NAFLD. Moreover, the different grades of NAFLD were not related to H. pylori infection.ConclusionsThese results indicate that H. pylori infection is not an independent risk factor for NAFLD in China.【 授权许可】
CC BY
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