Nanoscale Drug Delivery Systems in Glioblastoma

Nanoscale Research Letters

Qian Liu¹  Dong He²  Rui Zhang²  Zihao Liu²  Xiaoshuai Ji³  Tao Xin⁴ 

[1] Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, 250012, Jinan, China;Department of Neurosurgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, 250021, Jinan, China;Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, 250014, Jinan, China;Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, 250014, Jinan, China;Department of Neurosurgery, Shandong Provincial Qianfoshan Hospital, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Medicine and Health Key Laboratory of Neurosurgery, 250014, Jinan, China;Department of Neurosurgery, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, 330006, Nanchang Jiangxi, China;

关键词: Glioblastoma;    Nanoparticles;    Biomaterials;    Drug delivery systems;   

DOI  :  10.1186/s11671-022-03668-6

来源: Springer

【 摘 要 】

Glioblastoma is the most aggressive cerebral tumor in adults. However, the current pharmaceuticals in GBM treatment are mainly restricted to few chemotherapeutic drugs and have limited efficacy. Therefore, various nanoscale biomaterials that possess distinct structure and unique property were constructed as vehicles to precisely deliver molecules with potential therapeutic effect. In this review, nanoparticle drug delivery systems including CNTs, GBNs, C-dots, MOFs, Liposomes, MSNs, GNPs, PMs, Dendrimers and Nanogel were exemplified. The advantages and disadvantages of these nanoparticles in GBM treatment were illustrated.

【 授权许可】

CC BY