Urinary bladder Schistosoma haematobium-related squamous cell carcinoma: a report of two fatal cases and literature review

Tropical Diseases, Travel Medicine and Vaccines

Haboubacar Chaibou Sodé¹  Hassan Nouhou²  Aïchatou Balaraba Abani Bako³  Boubacar Efared⁴  Daouda Alhousseini⁵  Habiba Salifou Boureima⁶  Boubacar Idrissa⁷ 

[1] Department of surgery, Niamey National Hospital, Niamey, Niger;Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger;Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger;General Referral Hospital, Niamey, Niger;Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger;Pathology laboratory, Niamey National Hospital, Niamey, Niger;Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger;Service of medical biology, Niamey National Hospital, Niamey, Niger;General Referral Hospital, Niamey, Niger;Pathology laboratory, Niamey National Hospital, Niamey, Niger;

关键词: Schistosomiasis;    Bladder cancer;    Squamous cell carcinoma;   

DOI  :  10.1186/s40794-022-00161-x

来源: Springer

【 摘 要 】

BackgroundSchistosomiasis is still a public health issue in certain areas of developing countries (especially in sub-saharan Africa). Schistosoma haematobium is a proven carcinogenic agent that causes mainly bladder squamous cell carcinoma. This type of cancer has characteristic epidemiological, clinical and histopathological features with poor prognosis as compared to other urinary bladder cancers not associated with this parasite.Cases presentationWe report two fatal cases of advanced-stage bladder squamous cell carcinoma associated with Schistosoma haematobium in a sub-saharan developing African country (Niger), illustrating the devastating complications of this tropical neglected disease. The two cases were a 38-year-old woman and a 37-year-old male. They presented with chronic pelvic pain and hematuria. The clinical and radiological work-up revealed invasive urivary bladder tumor extended to the pelvis, that was histopathologically proven to be an invasive squamous cell carcinoma associated with Schistosoma haematobium. The two patients died shortly after the diagnosis before chemotherapy prescription.ConclusionSchistosoma-associated bladder squamous cell carcinoma has characteristic features with dismal prognosis. Eradication of this parasite remains the only efficient way to prevent the devastating consequences of this particular cancer.

【 授权许可】

CC BY