Inter-society consensus for the use of inhaled corticosteroids in infants, children and adolescents with airway diseases

Italian Journal of Pediatrics

Francesco Macrì¹  Attilio Varricchio²  Valter Spanevello³  Giovanni Battista Pajno⁴  Vito Leonardo Miniello⁵  Diego Peroni⁶  Annalisa Capuano⁷  Gabriella Di Mauro⁷  Cristina Di Mauro⁷  Francesco Paravati⁸  Valeria Caldarelli⁹  Lucia Diaferio^1,10  Alberto Giuseppe Martelli^1,11  Giampaolo Ricci^1,12  Luciana Indinnimeo^1,13  Marzia Duse^1,13  Francesca Santamaria^1,14  Melissa Borrelli^1,14  Agostino Nocerino^1,15  Serenella Castronuovo^1,16  Anna Maria Zicari^1,17  Giovanna De Castro^1,17  Elio Novembre^1,18  Luca De Franciscis^1,19  Elena Chiappini^2,20  Dora Di Mauro^2,21  Francesco Di Mauro^2,22  Giuseppe Di Mauro^2,22  Carlo Caffarelli^2,23  Stefania Zanconato^2,24  Giovanni Cerimoniale^2,25  Sergio Renzo Morandini^2,25  Maria Carmen Verga^2,26  Adima Lamborghini^2,27  Renato Turra^2,28  Mariangela Tosca^2,29  Massimo Landi^3,30  Giovanni Corsello^3,31  Roberto Bernardini^3,32  Monica Malventano^3,33  Marcello Bergamini^3,33  Germana Nardini^3,34  Giovanni Simeone^3,35  Gabriella Pozzobon^3,36  Daniele Giovanni Ghiglioni^3,37  Caterina Di Mauro^3,38  Iride Dello Iacono^3,39  Lucia Leonardi^4,40  Fabio Midulla^4,40  Carlo Alfaro^4,41  Raffaele Falsaperla^4,42  Vassilios Fanos^4,43  Cristina Piersantelli^4,44  Paolo Becherucci^4,45  Riccardo Lubrano^4,46  Gianluigi Marseglia^4,47  Amelia Licari^4,47  Salvatore Barberi^4,48  Maria Elisa Di Cicco^4,49  Elena Galli^5,50  Ahmad Kantar^5,51  Giovanna Tezza^5,52  Renato Cutrera^5,53  Luigi Masini^5,54  Domenico Minasi^5,55  Paolo Biasci^5,56  Michele Miraglia del Giudice^5,57  Fabio Decimo^5,57  Carlo Capristo^5,57  Annamaria Bianchi^5,58  Giorgio Piacentini^5,59  Fabio Cardinale^6,60  Stefano Luciani^6,61  Mattia Doria^6,62  Valentina Ferraro^6,63  Alberto Villani^6,64 

[1] Allergist Pediatrician National Secretary of Italian Federation for Medical Scientific Societies (FISM), Rome, Italy;Allergy Centre, Department of Pediatric Sciences IRCCS Gaslini Institute, Genova, Italy;Alma Mater Studiorum, Univesity of Bologna, Bologna, Italy;Department Health Science, University of Florence, Florence, Italy;Department of Biomedical Science and Human Oncology, University of Bari, Children’s Hospital “Giovanni XXIII”, Bari, Italy;Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy;Department of Experimental Medicine, University “Luigi Vanvitelli”, Regional Centre of Pharmacovigilance Campania, Naples, Italy;Department of Human Pathology in Adult and Development Age, Pediatric Unit, University of Messina, Messina, Italy;Department of Obstetrics Gynaecology and Pediatrics, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy;Department of Paediatrics, Aldo Moro University of Bari, Bari, Italy;Department of Pediatrics G. Salvini Hospital Garbagnate Milanese, Milan, Italy;Department of Pediatrics, IRCC San Raffaele, Milan, Italy;Department of Pediatrics, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy;Department of Translational Medical Sciences, Federico II University, Naples, Italy;Department of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy;Department of Woman, Child and of General and Specialized Surgery, University “Luigi Vanvitelli”, Naples, Italy;Departmental Operative Unit of Diagnostic and Surgical Videoendoscopy of the Upper Airways, Asl Napoli 1 Center, Naples, Italy;Division of Pediatrics, University Hospital of Udine, Udine, Italy;Endocrinologist Specialist, Salerno, Italy;Family Paediatrician Local Health Unit Nettuno-Anzio, Rome, Italy;Paediatric Infectious Disease Unit, Meyer Children’s University Hospital, Department Of Health Sciences, University of Florence, Florence, Italy;Family Paediatrician Local Health Unit, Ausl, Modena, Italy;Family Paediatrician, Local Health Unit, Caserta, Italy;Family Paediatrician, Local Health Unit, FIMP National President, Livorno, Italy;Family Pediatrician Local Health Unit Caselle Torinese, Turin, Italy;Family Pediatrician Local Health Unit Latina, Latina, Italy;Family Pediatrician Local Health Unit Salerno, Vietri sul Mare, Italy;Family Pediatrician Local Health Unit Teramo, Teramo, Italy;Family Pediatrician Local Health Unit, Caselle Torinese, Vicenza, Italy;Family Pediatrician Local Health Unit, Ferrara, Italy;Family Pediatrician Local Health Unit, Turin and IRIB-CNR, Palermo, Italy;Family Pediatrician, Local Health Unit Salerno, Aversa, Italy;Family Pediatrician, Local Health Unit Tuscany center, Florence, Italy;Family Pediatrician, Local Health Unit, Ferrara, Italy;Family Pediatrician, Local Health Unit, Latina, Italy;Family Pediatrician, Local Health Unit, Mesagne, Italy;Family Pediatrician, Paediatric Allergy, Local Health Unit TO1, Turin, Italy;Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, UOSD Paediatric Highly Intensive Care Unit, Milan, Italy;General Paediatrics and Paediatric Acute and Emergency Unit, University Hospital San Marco, University of Catania, Catania, Italy;Independent Paediatrician Researcher, Benevento, Italy;Maternal, Infantile and Urological Sciences Department, Sapienza University, Rome, Italy;Maternal, infantile and urological sciences Department, Pediatric Allergic Unit, Sapienza University, Rome, Italy;Neonatal Intensive Care Unit and Neonatal Accompaniment Unit, University Hospital San Marco, University of Catania, Catania, Italy;Neonatal Intensive Care Unit, Neonatal Pathology and Neonatal Section, AOU and University of Cagliari, Monserrato (CA), Italy;Paediatric Section Department of Surgery, Dentistry, Paediatrics and Gynaecology University of Verona, Verona, Italy;Paediatric Unit, ASST-Rhodense, RHO, Italy;Paediatric and Neonatology Unit Santa Maria Goretti Hospital, Department of Pediatrics, Sapienza University, Rome, Italy;Paediatric and Neonatology Unit Santa Maria Goretti Hospital, Department of Pediatrics, University of Pavia, Pavia, Italy;Paediatrics Unit, Reunited Hospitals Castellammare of Stabia, Naples, Italy;Paediatrics Unit, University Hospital of Pisa, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;Pediatric Allergy Unit, Department of Paediatric Medicine, S. Pietro Hospital Fatebenefratelli, Rome, Italy;Pediatric Asthma and Cough Center Istituti Ospedalieri Bergamaschi, Gruppo Ospedaliero San Donato, Ponte San Pietro, Bergamo, Italy;Pediatric Department, Franz Tappeiner Hospital, Meran, Italy;Pediatric Pulmonology Unit, Academic Department of Paediatrics, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy;Pediatric Pulmonology and Subintensive Respiratory Therapy Unit Department of Pediatrics Santobono-Pausilipon Children’s Hospital, Naples, Italy;Pediatric Unit Great Metropolitan Hospital Reggio Calabria, Reggio Calabria, Italy;Pediatric Unit San Giuseppe Hospital, Empoli, Florence, Italy;Pediatric Unit, Department of Mother and Child, AUSL-IRCCS, Reggio Emilia, Italy;Pediatric Unit, Department of Women’s and Children’s Health, San Camillo Forlanini Hospital, Rome, Italy;Pediatric Unit, S. Giovanni di Dio Hospital, Crotone, Italy;Pediatric and Emergency Unit Giovanni XXIII Pediatric Hospital University of Bari, Bari, Italy;Pediatric and Neonatal Intensive Care Unit Fatebenefratelli Isola Tiberina, Rome, Italy;Primary Care Paediatrician, Local Health Unit, National Secretary for the Scientific and Ethical Activities of FIMP, Chioggia, Italy;Unit of Paediatric Allergy and Respiratory Medicine Women’s and Children’s Health Department, University Hospital Padua, Padua, Italy;Unit of Pediatric Allergy and Respiratory Medicine Women’s and Children’s Health Department University Hospital, Padua, Italy;

关键词: Inhaled corticosteroids;    Asthma;    Wheezing;    Rhinitis;    Rhinosinusitis;    Laryngospasm;    Laryngotracheitis;    Adenoid hypertrophy;   

DOI  :  10.1186/s13052-021-01013-8

来源: Springer

【 摘 要 】

BackgroundIn 2019, a multidisciplinary panel of experts from eight Italian scientific paediatric societies developed a consensus document for the use of inhaled corticosteroids in the management and prevention of the most common paediatric airways disorders. The aim is to provide healthcare providers with a multidisciplinary document including indications useful in the clinical practice. The consensus document was intended to be addressed to paediatricians who work in the Paediatric Divisions, the Primary Care Services and the Emergency Departments, as well as to Residents or PhD students, paediatric nurses and specialists or consultants in paediatric pulmonology, allergy, infectious diseases, and ear, nose, and throat medicine.MethodsClinical questions identifying Population, Intervention(s), Comparison and Outcome(s) were addressed by methodologists and a general agreement on the topics and the strength of the recommendations (according to the GRADE system) was obtained following the Delphi method. The literature selection included secondary sources such as evidence-based guidelines and systematic reviews and was integrated with primary studies subsequently published.ResultsThe expert panel provided a number of recommendations on the use of inhaled corticosteroids in preschool wheezing, bronchial asthma, allergic and non-allergic rhinitis, acute and chronic rhinosinusitis, adenoid hypertrophy, laryngitis and laryngospasm.ConclusionsWe provided a multidisciplinary update on the current recommendations for the management and prevention of the most common paediatric airways disorders requiring inhaled corticosteroids, in order to share useful indications, identify gaps in knowledge and drive future research.

【 授权许可】

CC BY