Association of preconception dysmenorrhea with obstetric complications: the Japan Environment and Children’s Study

BMC Pregnancy and Childbirth

Kosei Shinoki¹  Akiko Sato¹  Yuka Ogata¹  Keiya Fujimori²  Akiko Yamaguchi²  Toma Fukuda²  Shun Yasuda²  Tsuyoshi Murata²  Hyo Kyozuka²  Yuta Endo²  Mitsuaki Hosoya³  Koichi Hashimoto³  Seiji Yasumura⁴  Hidekazu Nishigori⁵ 

[1] Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Department of Public Health, Fukushima Medical University School of Medicine, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Fukushima Regional Center for the Japan Environment and Children’s Study, 1 Hikarigaoka, 960-1295, Fukushima, Japan;Fukushima Medical Center for Children and Women, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan;

关键词: Preconception dysmenorrhea;    Preterm birth;    Small-for-gestational-age infant;    Preterm premature rupture of membrane;    Hypertensive disorders of pregnancy;   

DOI  :  10.1186/s12884-021-04347-7

来源: Springer

【 摘 要 】

BackgroundThe association of maternal preconception dysmenorrhea, especially primary dysmenorrhea, with obstetric complications has not been clearly described. Therefore, we evaluated the association of preconception dysmenorrhea with obstetric complications while accounting for the presence of pelvic pathologies.MethodsWe analyzed the data of women with singleton live births at and after 22 weeks of gestation enrolled in the Japan Environment and Children’s Study, a nationwide birth cohort study, between 2011 and 2014. Participants with psychological disorders were excluded. Preconception dysmenorrhea, identified in the medical record transcripts, was categorized into mild dysmenorrhea (MD) and severe dysmenorrhea (SD). Furthermore, excluding those who had pelvic pathologies via self-reported questionnaires (endometriosis, adenomyosis, and uterine myomas) with MD and SD, preconception dysmenorrhea was categorized into mild primary dysmenorrhea (MPD) and severe primary dysmenorrhea (SPD), respectively. Using multiple logistic regression, adjusted odds ratios (aORs) for obstetric complications, including preterm birth (PTB) before 37 weeks and 34 weeks, small-for-gestational-age infants, preterm premature rupture of membrane, and hypertensive disorders of pregnancy, were calculated (considering confounders) in women with (1) MD or SD and (2) MPD or SPD. Women without preconception dysmenorrhea were used as a reference.ResultsA total of 80,242 participants were analyzed. In women with SD, the aOR for PTB before 37 weeks was 1.38 (95% confidence interval [CI] 1.10, 1.72). In women with SPD, the aOR for PTB before 37 weeks was 1.32 (95% CI 1.02, 1.71). There was no association between women with MD or MPD and obstetric complications.ConclusionsSD and SPD are significantly associated with an increased incidence of PTB before 37 weeks. Care providers should provide proper counseling regarding the association between preconception dysmenorrhea and obstetric complications. Optimal management of pregnant women with preconception dysmenorrhea to reduce the incidence of PTB should be elucidated in further studies, with detailed clinical data of pelvic pathologies.

【 授权许可】

CC BY