Comparison of different surgical methods and strategies for inguinal lymph node dissection in patients with penile cancer

Scientific Reports

Xu Hu¹  Kan Wu¹  Xiang Li¹  Weixiao Yang¹  Yanxiang Shao¹  Yaohui Wang¹  Yang Liu¹  Sanchao Xiong¹  Shuyang Feng¹  Thongher Lia¹  Zhen Yang²  Duwu Liao³  Shangqing Ren⁴ 

[1] Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37 GuoXueXiang, 610041, Chengdu, People’s Republic of China;Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37 GuoXueXiang, 610041, Chengdu, People’s Republic of China;Department of Urology, Chengdu Second People’s Hospital, Chengdu, People’s Republic of China;Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37 GuoXueXiang, 610041, Chengdu, People’s Republic of China;Department of Urology, Nuclear Industry 416 Hospital, Chengdu, People’s Republic of China;Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37 GuoXueXiang, 610041, Chengdu, People’s Republic of China;Robotic Minimally Invasive Surgery Center, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, People’s Republic of China;

DOI  :  10.1038/s41598-022-06494-z

来源: Springer

【 摘 要 】

To compare the clinical feasibility and oncological outcome of different surgical techniques for inguinal lymphadenectomy (ILND) in patients suffering from penile cancer. This study included data from 109 cN0–2 patients diagnosed with penile cancer who received ILND. 80 laparoscopic ILND were performed on 40 patients, while 138 open surgeries were performed on 69 patients. Perioperative complications and prognosis were compared between different surgical techniques. Compared with the open surgery group, the laparoscopy group had a shorter hospital stay (8.88 ± 7.86 days vs. 13.94 ± 10.09 days, P = 0.004), and a lower wound healing delay rate (8.75% vs. 22.46%, P = 0.017), but also had longer drainage time (10.91 ± 9.66 vs. 8.70 ± 4.62, P = 0.002). There were no significant differences in terms of other intraoperative parameters, complications, and survival between open and laparoscopic group. Compared with saphenous vein ligated subgroup, preserved subgroup showed no significant reducing of complication rate. There was no significant difference among complication between different open surgery subgroup. Immediate ILND showed no prognostic advantage over delayed ILND regardless of clinical lymph node status. Compared with open surgery, the minimally invasive ILND technique has similar oncological efficiency and a lower complication rate. Saphenous vein preservation has limited value in reducing complications. Delayed lymphadenectomy might be a more reasonable option for ILND.

【 授权许可】

CC BY