The impact of race and ethnicity in breast cancer—disparities and implications for precision oncology

BMC Medicine

Alex Daly¹  Ramsey I. Cutress¹  Ellen R. Copson¹  Kelly A. Hirko²  Erica Reasor³  Gabrielle Rocque³  Ammanuel Taye³  Dae-Won Lee⁴  Kyung-Hun Lee⁴  Seock-Ah Im⁴  Yeon Hee Park⁵ 

[1] Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton and University Hospital Southampton, SO16 6YD, Southampton, UK;Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, 48824, East Lansing, MI, USA;Department of Internal Medicine, Division of Hematology Oncology, O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA;Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea;Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea;Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro Gangnam-gu, 06351, Seoul, Korea;

关键词: Breast cancer;    Race;    Ethnicity;    Disparities;    Clinical outcomes;    Socioeconomic status;    CDK4/6 inhibitors;    PARP inhibitors;    BRCA mutations;    Targeted therapy;    Precision oncology;   

DOI  :  10.1186/s12916-022-02260-0

来源: Springer

【 摘 要 】

Breast cancer is the most commonly diagnosed cancer worldwide and is one of the leading causes of cancer death. The incidence, pathological features, and clinical outcomes in breast cancer differ by geographical distribution and across racial and ethnic populations. Importantly, racial and ethnic diversity in breast cancer clinical trials is lacking, with both Blacks and Hispanics underrepresented. In this forum article, breast cancer researchers from across the globe discuss the factors contributing to racial and ethnic breast cancer disparities and highlight specific implications of precision oncology approaches for equitable provision of breast cancer care to improve outcomes and address disparities.

【 授权许可】

CC BY