Elevation of MMP1 and ADAMTS5 mRNA expression in glenohumeral synovia of patients with hypercholesterolemia

Journal of Orthopaedic Surgery and Research

Ryo Tazawa¹  Tomonori Kenmoku¹  Kyoko Muneshige¹  Gen Inoue¹  Mitsufumi Nakawaki¹  Daisuke Ishii¹  Masashi Takaso¹  Kentaro Uchida² 

[1] Department of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku, Kitasato, 252-0374, Sagamihara City, Kanagawa, Japan;Department of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku, Kitasato, 252-0374, Sagamihara City, Kanagawa, Japan;Shonan University of Medical Sciences Research Institute, Nishikubo 500, 253-0083, Chigasaki City, Kanagawa, Japan;

关键词: Osteoarthritis;    Hypercholesterolemia;    ADAMTS5;    MMP1;    Synovium;   

DOI  :  10.1186/s13018-022-02998-6

来源: Springer

【 摘 要 】

BackgroundEpidemiological studies have reported a positive association between hypercholesterolemia and shoulder disease. Previous studies have focused on the effect of hypercholesterolemia on tendinopathy. Moreover, hypercholesterolemia has also been linked to joint pathology in the knee and hand. However, the effect of hyperlipidemia on glenohumeral joint remain unclear. A hypercholesterolemic condition has been reported to alter levels of A Disintegrin and Metalloprotease with Thrombospondin Motifs (ADAMTSs) and matrix metalloproteases (MMPs) in synovium of the knee joint. Here, we evaluated the mRNA expression of ADAMTSs and MMPs in the glenohumeral synovium of patients with and without hypercholesterolemia.MethodsStudy participants were 73 patients who underwent arthroscopic rotator cuff repair for degenerative rotator cuff tears. They were divided into two groups according to total cholesterol (TC) and triglyceride levels. Synovial membrane samples were harvested at the rotator interval during surgery, and mRNA expression levels of the aggrecanases ADAM-TS4 and ADAM-TS5 and MMPs (MMP-1, 3, 9, and 13) were analyzed quantitatively.ResultsADAM-TS5 and MMP1 mRNA levels were significantly higher in the high TC group than in the low TC group (P = 0.023 and P = 0.025, respectively). In contrast, no significant differences were observed in ADAMTS4 or MMPs 3, 9, and 13 (ADAMTS4, P = 0.547; MMP3, P = 0.55; MMP9, P = 0.521; and MMP13, P = 0.785).ConclusionHypercholesterolemia may alter MMP1 and ADAMTS5 expression in the synovium of the glenohumeral joint.

【 授权许可】

CC BY