(Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders

Lipids in Health and Disease

Jyoti Sihag¹  Vincenzo Di Marzo² 

[1] Faculty of Medicine, University of Laval, Quebec, Canada;Faculty of Agriculture and Food Sciences, University of Laval, Quebec, Canada;Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), University of Laval, Quebec, Canada;University Institute of Cardiology and Pneumology, Quebec, Canada;Institute of Nutrition and Functional Foods (INAF) and Centre Nutrition, Santé et Société (NUTRISS), University of Laval, Quebec, Canada;Department of Foods and Nutrition, Chaudhary Charan Singh Haryana Agricultural University, Hisar, India;Faculty of Medicine, University of Laval, Quebec, Canada;Faculty of Agriculture and Food Sciences, University of Laval, Quebec, Canada;Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health (CERC-MEND), University of Laval, Quebec, Canada;University Institute of Cardiology and Pneumology, Quebec, Canada;Institute of Nutrition and Functional Foods (INAF) and Centre Nutrition, Santé et Société (NUTRISS), University of Laval, Quebec, Canada;Institute of Biomolecular Chemistry of the National Research Council (ICB-CNR), Naples, Italy;Endocannabinoid Research Group, Naples, Italy;Joint International Research Unit between the Italian National Research Council (CNR) and University of Laval, for Chemical and Biomolecular Research on the Microbiome and its impact on Metabolic Health and Nutrition (UMI-MicroMeNu), Quebec, Canada;

关键词: Endocannabinoids;    Endocannabinoidome;    Microbiome;    Nutrition;    Obesity;   

DOI  :  10.1186/s12944-021-01609-3

来源: Springer

【 摘 要 】

The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet to be elucidated functional lipid mediators and receptors. The diet modulates these bioactive lipids and the gut microbiome, both working in an entwined alliance. Mounting evidence suggests that, in different ways and with a certain specialisation, lipid signalling mediators such as N-acylethanolamines (NAEs), 2-monoacylglycerols (2-MAGs), and N-acyl-amino acids (NAAs), along with endocannabinoids (eCBs), can modulate physiological mechanisms underpinning appetite, food intake, macronutrient metabolism, pain sensation, blood pressure, mood, cognition, and immunity. This knowledge has been primarily utilised in pharmacology and medicine to develop many drugs targeting the fine and specific molecular pathways orchestrating eCB and eCBome activity. Conversely, the contribution of dietary NAEs, 2-MAGs and eCBs to the biological functions of these molecules has been little studied. In this review, we discuss the importance of (Wh) olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N) utrition (WHEN), in the management of obesity and related disorders.

【 授权许可】

CC BY