The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin

Epigenetics & Chromatin

Soojin Yeom¹  Jiyeon Park¹  Junsoo Oh¹  Jung-Shin Lee¹ 

[1] Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, 1 Kangwondeahak-gil, 24341, Chuncheon, Republic of Korea;

关键词: Saccharomyces cerevisiae;    Schizosaccharomyces pombe;    Heterochromatin structural proteins;    SIR complex;    Swi6;   

DOI  :  10.1186/s13072-022-00435-w

来源: Springer

【 摘 要 】

Budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe are good models for heterochromatin study. In S. pombe, H3K9 methylation and Swi6, an ortholog of mammalian HP1, lead to heterochromatin formation. However, S. cerevisiae does not have known epigenetic silencing markers and instead has Sir proteins to regulate silent chromatin formation. Although S. cerevisiae and S. pombe form and maintain heterochromatin via mechanisms that appear to be fundamentally different, they share important common features in the heterochromatin structural proteins. Heterochromatin loci are localized at the nuclear periphery by binding to perinuclear membrane proteins, thereby producing distinct heterochromatin foci, which sequester heterochromatin structural proteins. In this review, we discuss the nuclear peripheral anchoring of heterochromatin foci and its functional relevance to heterochromatin formation and maintenance.Graphical Abstract

【 授权许可】

CC BY