Investigation of respiratory rate in patients with cystic fibrosis using a minimal-impact biomotion system

BMC Pulmonary Medicine

Christoph Schöbel¹  Gerhard Weinreich²  Sivagurunathan Sutharsan²  Matthias Welsner²  Svenja Straßburg²  Christian Taube²  Carolin-Maria Linker³  Jürgen Götze⁴  Florian Stehling⁵  Sebastian Brato⁶ 

[1] Center of Sleep and Telemedicine, University Medicine Essen – Ruhrlandklinik, University Duisburg-Essen, Essen, Germany;Department of Pneumology, University Medicine Essen – Ruhrlandklinik, University Duisburg-Essen, Tüschener Weg 40, 45239, Essen, Germany;Department of Pneumology, University Medicine Essen – Ruhrlandklinik, University Duisburg-Essen, Tüschener Weg 40, 45239, Essen, Germany;Information Processing Lab, Faculty of Electrical Engineering, Information Engineering - TU Dortmund, Dortmund, Germany;Information Processing Lab, Faculty of Electrical Engineering, Information Engineering - TU Dortmund, Dortmund, Germany;Pediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Center, Children’S Hospital, University Duisburg-Essen, Essen, Germany;SWG Sportwerk GmbH & Co. KG, Dortmund, Germany;

关键词: Cystic fibrosis;    Respiratory rate;    Telemedicine;    Home monitoring;    Exacerbation;   

DOI  :  10.1186/s12890-022-01855-w

来源: Springer

【 摘 要 】

BackgroundIn this study we tested the hypothesis that in patients with cystic fibrosis (pwCF) respiratory rate (RR) is associated with antibiotic treatment, exacerbation status, forced expiratory volume in one second (FEV1) and C-reactive protein (CRP).MethodsBetween June 2018 and May 2019, we consecutively enrolled pwCF who were referred to our hospital. We determined RR and heart rate (HR) by using the minimal-impact system VitaLog during the hospital stay. Furthermore, we performed spirometry and evaluated CRP.ResultsWe included 47 patients: 20 with pulmonary exacerbation and 27 without. RR decreased in patients with exacerbation (27.5/min (6.0/min) vs. 24.4/min (6.0/min), p = 0.004) and in patients with non-exacerbation (22.5/min (5.0/min) vs. 20.9/min (3.5/min), p = 0.024). Patients with exacerbation showed higher RR than patients with non-exacerbation both at the beginning (p = 0.004) and at the end of their hospital stay (p = 0.023). During the hospital stay, HR did not change in the total cohort (66.8/min (11.0/min) vs. 66.6/min (12.0/min), p = 0.440). Furthermore, we did not find significant differences between patients with exacerbation and patients with non-exacerbation (67.0/min (12.5/min) vs. 66.5/min (10.8/min), p = 0.658). We observed a correlation of ρ = -0.36 between RR and FEV1. Moreover, we found a correlation of ρ = 0.52 between RR and CRP.ConclusionIn pwCF requiring intravenous therapy, respiratory rate is higher at their hospital admittance and decreased by the time of discharge; it is also associated with C-reactive protein. Monitoring RR could provide important information about the overall clinical conditions of pwCF.

【 授权许可】

CC BY