期刊论文详细信息
Journal of Translational Medicine
Elevated mid-trimester 4-h postprandial triglycerides for predicting late-onset preeclampsia: a prospective screening study
Wen Cai1  Qing Liu2  ShuangDi Li2  Zhihong Zhu3  Liu Yang3  Jiarong Zhang4 
[1] Department of Obstetrics and Gynecology, ShangHai General Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, China;Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, 2699 Gaoke West Road, Shanghai, China;Department of Obstetrics and Gynecology, Shanghai ZhongShan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China;Department of Obstetrics and Gynecology, Shanghai ZhongShan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China;Department of Obstetrics and Gynecology, ShangHai General Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, China;
关键词: Hypertriglyceridemia;    Preeclampsia;    OLTT;    Prediction;    Metabolism;   
DOI  :  10.1186/s12967-022-03261-6
来源: Springer
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【 摘 要 】

BackgroundAbnormal maternal lipid concentrations are associated with increased risk of preeclampsia. However, previous studies mainly focused on fasting lipid concentrations, scarce data have been published on the relationship between postprandial triglyceride (TG) concentrations in the second trimester and the risk of preeclampsia. Our aim is to evaluate the potential of triglyceride (TG) concentrations at the time of oral lipid tolerance test (OLTT) measurement in the second trimester to predict preeclampsia and to elucidate the lipid metabolic changes related to these diseases.MethodsThis is a prospective cohort study of Pregnant women at 12–24 weeks of gestation undergone an OLTT in a university affiliated hospital between May 2019 and January 2020. Data were stratified into binaries according to the OLTT results. The receiver operating characteristic (ROC) curve analysis was conducted to determine the optimal cut-off points of TG, HDL-C, LDL-C, sd-LDL, FFA, and BG for predicting preeclampsia.Results438 pregnant women were recruited to undergo an OLTT at 12–24 weeks of gestation. Among these, 24 women developed preeclampsia and 414 women remained normotensive. Women who subsequently developed preeclampsia had higher concentrations of 4-h postprandial TG than those who remained normotensive. In the linear logistic regression analyses of potential confounding factors, mid-trimester 4-h postprandial TG concentrations at the time of OLTT measurement were significantly higher in preeclamptic cases than in controls.ConclusionsDyslipidemia in the second trimester of pregnancy, particularly postprandial hypertriglyceridemia, appears to be associated with an increased risk of preeclampsia. Mid-trimester 4-h postprandial TG concentration at the time of OLTT measurement may be a potential predictive marker of preeclampsia.Trial registration Data of registration: 2018/10/15. Date of initial participant enrollment: 2019/05/01. Clinical trial identification number: chiCTR1800018884. URL of the registration site: http://www.chictr.org.cn/showproj.aspx?proj=25526. Data sharing information: The data including individual participant data, detailed study protocols, statistical analysis plans will be shared upon request to the corresponding author.

【 授权许可】

CC BY   

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