Studying the post-COVID-19 condition: research challenges, strategies, and importance of Core Outcome Set development

BMC Medicine

Jennifer R. Chevinsky¹  Sharon Saydah²  Jochen Schmitt³  Jacobus Preller⁴  Frances Simpson⁵  Regis Goulart Rosa⁶  Sarah L. Gorst⁷  Frederikus A. Klok⁸  Daniel Munblit⁹  Sergey Avdeev^1,10  Danilo Buonsenso^1,11  Jessica Chen^1,12  Callum Parr^1,12  Louise Sigfrid^1,13  Piero Olliaro^1,14  Melina Michelen^1,15  Timothy R. Nicholson^1,16  Christian Apfelbacher^1,17  Margaret Herridge^1,18  Margaret E. O’Hara^1,19  Janet T. Scott^2,20  Paula R. Williamson^2,21  Ramachandran Thiruvengadam^2,22  Shinjini Bhatnagar^2,22  Wouter De Groote^2,23  Janet V. Diaz^2,23  Ann M. Parker^2,24  Dale M. Needham^2,25  Jon Genuneit^2,26  John O. Warner^2,27  Alisa Kokorina^2,28  Alla Guekht^2,29  Athena Akrami^3,30  Charitini Stavropoulou^3,31  Nina Seylanova^3,32  Allison Tong^3,33  Alan Asmanov^3,34  Luis Felipe Reyes^3,35  Nicoline Schiess^3,36 

[1] COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA;Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA;COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA;Respiratory Viruses Branch, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA;Center for Evidence-Based Healthcare, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany;Clinical Management, WHO, WHE, Geneva, Switzerland;Coventry University, Coventry, UK;Critical Care Department, Hospital Moinhos de Vento, Porto Alegre, Brazil;Brazilian Research in Intensive Care Network (BRICNet), São Paulo, Brazil;Department of Health Data Science, University of Liverpool, Liverpool, UK;Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands;Department of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;Inflammation, Repair and Development Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK;Research and Clinical Center for Neuropsychiatry, Moscow, Russia;Department of Pulmonology, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy;Global Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, Roma, Italy;Faculty of Medicine, Imperial College London, London, UK;ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK;ISARIC Global Support Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK;ISARIC Global Support Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK;School of Health Sciences, City, University of London, London, UK;Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK;Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany;Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada;Department of Medicine, University Health Network, Toronto, ON, Canada;Long COVID Support, London, UK;MRC-University of Glasgow, Centre for Virus Research, Glasgow, UK;MRC/NIHR Trials Methodology Research Partnership, Department of Health Data Science, University of Liverpool (a member of Liverpool Health Partners), Liverpool, UK;Maternal and Child Health Program, Translational Health Science and Technology Institute, Faridabad, Delhi, National Capital Region, India;NCD Department, Rehabilitation Programme, WHO, Geneva, Switzerland;Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD, USA;Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Outcomes After Critical Illness and Surgery (OACIS) Research Group, Johns Hopkins University, Baltimore, MD, USA;Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Paediatric Epidemiology, Department of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany;Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK;Pirogov Russian National Research Medical University, Moscow, Russia;Research and Clinical Center for Neuropsychiatry, Moscow, Russia;Pirogov Russian National Research Medical University, Moscow, Russia;Sainsbury Wellcome Centre, UCL, London, UK;Patient-Led Research Collaborative, Washington, DC, USA;School of Health Sciences, City, University of London, London, UK;Sechenov Biomedical Science and Technology Park, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia;Sydney School of Public Health, The University of Sydney, Sydney, Australia;The Research and Clinical Institute for Pediatrics named after Academician Yuri Veltischev of the Pirogov Russian National Research Medical University, Moscow, Russia;Universidad de La Sabana, Chía, Colombia;Clínica Universidad de La Sabana, Chía, Colombia;WHO Brain Health Unit, Geneva, Switzerland;

关键词: COVID-19;    COVID-19 sequalae;    Long COVID;    Post-acute sequelae of SARS-CoV-2 infection;    PASC;    Post-COVID-19 condition;    Outcomes;    Core Outcome Set;   

DOI  :  10.1186/s12916-021-02222-y

来源: Springer

【 摘 要 】

BackgroundA substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness of breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to as long COVID but also known as post-acute sequelae of SARS-CoV-2 infection (PASC) or post-COVID-19 condition, could become a significant global health burden.Main textWhile the number of studies investigating the post-COVID-19 condition is increasing, there is no agreement on how this new disease should be defined and diagnosed in clinical practice and what relevant outcomes to measure. There is an urgent need to optimise and standardise outcome measures for this important patient group both for clinical services and for research and to allow comparing and pooling of data.ConclusionsA Core Outcome Set for post-COVID-19 condition should be developed in the shortest time frame possible, for improvement in data quality, harmonisation, and comparability between different geographical locations. We call for a global initiative, involving all relevant partners, including, but not limited to, healthcare professionals, researchers, methodologists, patients, and caregivers. We urge coordinated actions aiming to develop a Core Outcome Set (COS) for post-COVID-19 condition in both the adult and paediatric populations.

【 授权许可】

CC BY