Red Blood Cell-Mimic Nanocatalyst Triggering Radical Storm to Augment Cancer Immunotherapy

Nano-Micro Letters

Jiong Li¹  Sijia Wang¹  Zhenxi Zhang¹  Jing Wang¹  Cuiping Yao¹  Xinyi Lin¹  Xiaolong Liu²  Zhixiong Cai²  Ming Wu²  Yanbing Cao² 

[1] Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Biomedical Photonics and Sensing, School of Life Science and Technology, Xi’an Jiaotong University, 710049, Xi’an, People’s Republic of China;The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, 350025, Fuzhou, People’s Republic of China;Mengchao Med-X Center, Fuzhou University, 350116, Fuzhou, People’s Republic of China;

关键词: Red blood cell mimic;    Metal–organic framework;    Nanocatalyst;    Radical storm;    Cancer immunotherapy;   

DOI  :  10.1007/s40820-022-00801-z

来源: Springer

【 摘 要 】

tsA red blood cell-mimic nanocatalyst with photodynamic/chemodynamic-like, catalase-like and glutathione peroxidase-like activities was developed to boost radical storms for tumor eradication.Combined with the Tim-3 immune checkpoint blockade, such radical therapy can systematically evoke a robust systemic antitumor immune response to eliminate residual cancer cells.

【 授权许可】

CC BY