Platelet-rich plasma (PRP) augmentation does not result in more favourable outcomes in arthroscopic meniscal repair: a meta-analysis

Journal of Orthopaedics and Traumatology

Lucio Cipollaro¹  Francesco Cuozzo¹  Francesco Oliva¹  Nicola Maffulli²  Filippo Migliorini³  Frank Hildebrand³ 

[1] Department of Medicine, Surgery and Dentistry, University of Salerno, 84081, Baronissi, SA, Italy;Clinica Ortopedica, Ospedale San Giovanni di Dio e Ruggi d’Aragona, 84131, Salerno, Italy;Department of Medicine, Surgery and Dentistry, University of Salerno, 84081, Baronissi, SA, Italy;Clinica Ortopedica, Ospedale San Giovanni di Dio e Ruggi d’Aragona, 84131, Salerno, Italy;School of Pharmacy and Bioengineering, Faculty of Medicine, Keele University, Thornburrow Drive, Stoke on Trent, England;Queen Mary University of London, Barts and the London School of Medicine and Dentistry, Centre for Sports and Exercise Medicine, Mile End Hospital, 275 Bancroft Road, E1 4DG, London, England;Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University Hospital, Pauwelsstraße 30, 52074, Aachen, Germany;

关键词: Meniscus;    Repair;    Arthroscopy;    Augmentation;    PRP;   

DOI  :  10.1186/s10195-022-00630-1

来源: Springer

【 摘 要 】

BackgroundThe efficacy and safety of platelet-rich plasma (PRP) augmentation for arthroscopic meniscal repair is controversial. This meta-analysis compared arthroscopic meniscal repair performed in isolation or augmented with PRP.MethodsThe present study was conducted according to PRISMA 2020 guidelines. Pubmed, Web of Science, Google Scholar and Embase were accessed in August 2021. All the clinical trials which compared arthroscopic meniscal repair performed in isolation or augmented with PRP were included.ResultsEight hundred thirty-seven patients were included: 38% (318 of 837 patients) were women; the mean age of the patients was 35.6 (range, 20.8–64.3) years; the mean follow-up was 26.2 (range, 6–54) months. Similarity was found in analogue scale (VAS) (P = 0.5) and Lysholm (P = 0.9), and International Knee Documentation Committee (IKDC) scores (P = 0.9). Similarity was found in the rate of failure (P = 0.4) and rate of revision (P = 0.07).ConclusionThe current published scientific evidence does not support PRP augmentation for arthroscopic meniscal repair.

【 授权许可】

CC BY