Unusual neurologic manifestations of Vogt-Koyanagi-Harada disease: a systematic literature review

BMC Neurology

Abdoul Kadir Ibrahim-Mamadou¹  Moussa Toudou-Daouda² 

[1] Department of Medicine and Medical Specialties, Regional Hospital Center of Dosso, Dosso, Niger;Department of Neurology, National Hospital of Niamey, PO Box 238, Niamey, Niger;

关键词: Nervous system;    Vogt-Koyanagi-Harada disease;    unusual neurologic manifestations;   

DOI  :  10.1186/s12883-022-02569-6

来源: Springer

【 摘 要 】

Background and PurposeThe usual neurologic manifestations of Vogt-Koyanagi-Harada (VKH) disease include aseptic meningitis and headaches. We performed the present study to review all unusual neurologic manifestations reported in VKH disease to summarize them.MethodsA literature search was performed in the English language on Scopus and Medline via PubMed from 1946 to July 31, 2021, by using the following terms: “Vogt Koyanagi Harada disease” OR “VKH disease” AND “Brain” OR “Spinal cord” OR “CNS” OR “Central nervous system” OR “Neurologic” OR “Peripheral nervous system” OR “Polyneuropathies. Our inclusion criteria were unusual neurologic manifestations of VKH disease.ResultsOur literature search yielded 417 total articles (PubMed = 334, Scopus = 83) from which 32 studies comprising 43 patients (22 men and 21 women, of which 62.8% were younger than 50 years) were included in this systematic literature review. Regarding the study design, all studies were case reports and published between 1981 and 2021. CNS involvement was the most reported (93%) in VKH disease. Peripheral nervous system involvement represents 7% of cases. The cerebral lesions were parenchymal inflammatory lesions in the white matter or posterior fossa with or no contrast enhancement (16.3%), leptomeningitis (9.3%), pachymeningitis (7%), meningoencephalitis (2.3%), ischemic stroke (4.6%), hemorrhagic stroke (2.3%), transient ischemic attack (2.3%), and hydrocephalus (2.3%). The optic nerve lesions were anterior ischemic optic neuropathy (20.9%) and optic neuritis (9.3%). Concerning spinal cord lesion, it was mainly myelitis (14%).ConclusionThis systematic literature review provides a summary of the different unusual neurologic manifestations reported in VKH disease.

【 授权许可】

CC BY