Role of the S100 protein family in rheumatoid arthritis

Arthritis Research & Therapy

Jun Li¹  Su-qin Yin¹  Cheng Huang¹  Xue-ni Niu¹  Sha Wu¹  Yuan-yuan Wu¹  Xiao-feng Li² 

[1] Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, 230032, Hefei, China;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, 230032, Hefei, China;Postdoctoral Station of Clinical Medicine of Anhui Medical University, Hefei, Anhui, China;

关键词: S100 protein;    Rheumatoid arthritis;    Synovial inflammation;    Pannus formation;    Bone erosion;   

DOI  :  10.1186/s13075-022-02727-8

来源: Springer

【 摘 要 】

Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma). The destruction of joints and surrounding tissues eventually causes joint deformities and dysfunction or even loss. The S100 protein family is one of the biggest subtribes in the calcium-binding protein family and has more than 20 members. The overexpression of most S100 proteins in rheumatoid arthritis is closely related to its pathogenesis. This paper reviews the relationship between S100 proteins and the occurrence and development of rheumatoid arthritis. It will provide insights into the development of new clinical diagnostic markers and therapeutic targets for rheumatoid arthritis.

【 授权许可】

CC BY