Interleukin-4 can play a role in allergic rhinitis patient during treatment with Zataria multiflora

Clinical and Molecular Allergy

Jalal Ghorbani¹  Nazila Ariaee¹  Farahzad Jabbari¹  Yaser Yadegari¹  Maryam Panahi²  Javad Asili³  Mohamad Shabestari⁴ 

[1] Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;Preventive Cardiovascular Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;

关键词: Allergic rhinitis;    Cytokines;    IL-4;    Shirazi thyme;    Zataria multiflora;   

DOI  :  10.1186/s12948-022-00169-w

来源: Springer

【 摘 要 】

BackgroundAllergic rhinitis is a widespread disorder across the globe. The Shirazi thyme (Zataria multiflora) has been shown to have considerable antioxidant and anti-inflammatory properties. This study assessed the effect of this herbal product on alterations in inflammatory/anti-inflammatory cytokines.MethodThis study was conducted on the bank sample before and after the intervention to measure interleukin-4, interleukin-5, and interferon -γ levels with the ELISA test method in a supernatant taken from the PBMC cell culture from 30 allergic rhinitis patients.ResultsThe IL-4 level had no significant difference between the two groups before the treatment. However, it had a significant increase in the case group after the treatment. The IL-5 level was significantly higher in the case group before the treatment. Nevertheless, there were no significant differences between the case and control groups after the treatment. Similarly, no significant differences were observed between the two groups considering IFN-γ before and after the treatment.ConclusionConsuming thyme with an increase in anti-inflammatory cytokine IL-4 and a decrease in IL-5 cytokine control inflammation and improvement in allergic rhinitis symptoms.Clinical trial details This clinical trial study was recorded at 22.5.2014 in the Iran Registry of Clinical Trials code: (IRCT2016121823235N6) https://www.irct.ir/trial/19852

【 授权许可】

CC BY