Diagnosing ventilator-associated pneumonia (VAP) in UK NHS ICUs: the perceived value and role of a novel optical technology

Diagnostic and Prognostic Research

T. Walsh¹  S. Graziadio²  A. Winter²  A. J. Simpson³  W. S. Jones³  J. Suklan⁴  K. Green⁴  A. J. Allen⁴  K. Dhaliwal⁵  J. Mair⁵  A. Bruce⁵  T. Craven⁶ 

[1] Edinburgh Critical Care Research Group, University of Edinburgh, Edinburgh, UK;NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle upon Tyne Hospitals Foundation Trust, NE1 4LP, Newcastle upon Tyne, UK;NIHR Newcastle In Vitro Diagnostics Co-operative, Newcastle upon Tyne Hospitals Foundation Trust, NE1 4LP, Newcastle upon Tyne, UK;NIHR Newcastle In Vitro Diagnostics Co-operative, Translational & Clinical Research Institute, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK;NIHR Newcastle In Vitro Diagnostics Co-operative, Translational & Clinical Research Institute, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK;Translational Healthcare Technologies Group, Queen’s Medical Research Institute, University of Edinburgh, EH16 4TJ, Edinburgh, UK;Translational Healthcare Technologies Group, Queen’s Medical Research Institute, University of Edinburgh, EH16 4TJ, Edinburgh, UK;Edinburgh Critical Care Research Group, University of Edinburgh, Edinburgh, UK;

关键词: Ventilator-associated pneumonia;    VAP;    Interviews;    Care pathway analysis;    Thematic analysis;   

DOI  :  10.1186/s41512-022-00117-x

来源: Springer

【 摘 要 】

BackgroundDiagnosing ventilator-associated pneumonia (VAP) in an intensive care unit (ICU) is a complex process. Our aim was to collect, evaluate and represent the information relating to current clinical practice for the diagnosis of VAP in UK NHS ICUs, and to explore the potential value and role of a novel diagnostic for VAP, which uses optical molecular alveoscopy to visualise the alveolar space.MethodsQualitative study performing semi-structured interviews with clinical experts. Interviews were recorded, transcribed, and thematically analysed. A flow diagram of the VAP patient pathway was elicited and validated with the expert interviewees. Fourteen clinicians were interviewed from a range of UK NHS hospitals: 12 ICU consultants, 1 professor of respiratory medicine and 1 professor of critical care.ResultsFive themes were identified, relating to [1] current practice for the diagnosis of VAP, [2] current clinical need in VAP diagnostics, [3] the potential value and role of the technology, [4] the barriers to adoption and [5] the evidence requirements for the technology, to help facilitate a successful adoption. These themes indicated that diagnosis of VAP is extremely difficult, as is the decision to stop antibiotic treatment. The analysis revealed that there is a clinical need for a diagnostic that provides an accurate and timely diagnosis of the causative pathogen, without the long delays associated with return of culture results, and which is not dangerous to the patient. It was determined that the technology would satisfy important aspects of this clinical need for diagnosing VAP (and pneumonia, more generally), but would require further evidence on safety and efficacy in the patient population to facilitate adoption.ConclusionsCare pathway analysis performed in this study was deemed accurate and representative of current practice for diagnosing VAP in a UK ICU as determined by relevant clinical experts, and explored the value and role of a novel diagnostic, which uses optical technology, and could streamline the diagnostic pathway for VAP and other pneumonias.

【 授权许可】

CC BY