Comparison of transepithelial and conventional photorefractive keratectomy in myopic and myopic astigmatism patients: a randomized contralateral trial

BMC Ophthalmology

Mohammad Miraftab¹  Hassan Hashemi¹  Soheila Asgari¹  Azam Alvani¹  Mohammadreza Aghamirsalim² 

[1] Noor Ophthalmology Research Center, Noor Eye Hospital, 96, Esfandiar Blvd, Valiasr St, 1968653111, Tehran, Tehran, Iran;Translational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Transepithelial photorefractive keratectomy;    mechanical epithelial debridement photorefractive keratectomy;    alcohol-assisted photorefractive keratectomy;    corneal epithelial defect area;    corneal epithelial healing rate;   

DOI  :  10.1186/s12886-022-02293-2

来源: Springer

【 摘 要 】

BackgroundTo assess transepithelial photorefractive keratectomy (tPRK) in terms of corneal epithelial healing rate, postoperative pain, postoperative discomfort, and visual and refraction outcomes compared to mechanical epithelial debridement PRK (mPRK) and alcohol-assisted PRK (aaPRK).MethodsIn this double-masked, randomized clinical trial, thirty-nine patients underwent tPRK in one eye and mPRK in the fellow eye (arm A), and 33 patients underwent tPRK in one eye and aaPRK in the contralateral eye (arm B). All surgical procedures were done using the Schwind Amaris excimer laser. The area of corneal epithelial defect in all eyes was captured and analyzed using ImageJ software.ResultsMean epithelial healing time was respectively 3.74 ± 0.82 and 3.59 ± 0.79 days in tPRK versus mPRK (P = 0.21) in arm A, and 3.67 ± 0.92 and 3.67 ± 0.74 days in tPRK versus aaPRK (P = 1.00) in arm B. Accounting for the initial corneal epithelial defect area, the epithelial healing rate was faster in conventional PRK groups compared to tPRK (both P<0.001) in both arms. However, there was no significant difference in safety, efficacy, spherical equivalent refractive accuracy, or corneal haze development between tPRK and conventional PRK groups (all P > 0.05).ConclusionsAll three methods are effective in terms of visual and refractive outcomes. However, although time to complete re-epithelialization was similar with the three methods, the epithelial healing rate was faster in conventional PRK considering the initial corneal epithelial defect area, and the patients experienced less pain and discomfort in the first postoperative day.Trial registrationIRCT, IRCT20200317046804N1. Retrospectively registered 5 May 2020.

【 授权许可】

CC BY