Severe tyrosine-kinase inhibitor induced liver injury in metastatic renal cell carcinoma patients: two case reports assessed for causality using the updated RUCAM and review of the literature

BMC Gastroenterology

Jindriska Volakova¹  Tomas Szotkowski²  Martina Spisarova³  Hana Studentova³  Anezka Zemankova³  Bohuslav Melichar⁴  Kvetoslava Aiglova⁵ 

[1] Deparment of Clinical Pharmacology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic;Department of Hemato-Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic;Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic;Department of Oncology, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic;Institute of Molecular and Translational Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic;Second Department of Internal Medicine, Palacký University Medical School and Teaching Hospital, Olomouc, Czech Republic;

关键词: Renal cell carcinoma;    TKI;    Drug induced liver injury (DILI);    Roussel Uclaf causality assessment method (RUCAM);    Fatal liver failure;    Clarithromycin;    Hepatotoxicity;   

DOI  :  10.1186/s12876-022-02121-3

来源: Springer

【 授权许可】

CC BY