The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters

BMC Genomics

Anna Cywińska¹  Monika Michałowska-Sawczyn²  Kinga Humińska-Lisowska²  Paweł Cięszczyk²  Agata Leońska-Duniec²  Andrzej Mastalerz³  Katarzyna Lorenz³  Ewelina Maculewicz⁴  Łukasz Dziuda⁵  Bożena Antkowiak⁶  Anna Borecka⁶  Oktawiusz Antkowiak⁶  Ewa Szarska⁶  Aleksandra Garbacz⁷ 

[1] Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, 87-100, Torun, Poland;Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336, Gdansk, Poland;Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809, Warsaw, Poland;Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809, Warsaw, Poland;Military Institute of Hygiene and Epidemiology, 01-163, Warsaw, Poland;Military Institute of Aviation Medicine, 01-755, Warsaw, Poland;Military Institute of Hygiene and Epidemiology, 01-163, Warsaw, Poland;Warsaw University of Life Sciences - SGGW, 02-787, Warsaw, Poland;

关键词: Genetic polymorphisms;    IL1A;    IL1B;    IL1RN;    Body mass index;    Fat percentage;   

DOI  :  10.1186/s12864-021-08258-x

来源: Springer

【 摘 要 】

BackgroundObesity has been recognized as a worldwide growing problem, producing many pathologies including the promotion of “proinflammatory state.” The etiology of human obesity is still only partially understood; however, the genetic background has been proved. Its nature is complex, and currently, it appears that the combined effects of the interactions among multiple genes should receive more attention. Due to the fact that obesity promotes proinflammatory conditions, in this study, we investigated the genetic polymorphism of IL-1 family genes in healthy people with normal and elevated body mass index (BMI) and fat %.ResultsThe single-nucleotide polymorphisms (SNPs) within the IL1A -889C > T (rs1800587), IL1B + 3954 T > C (rs1143634), and IL1RN -87G > A (rs2234677) genes alone were associated neither with BMI nor fat % values in tested group. The associations between SNP–SNP interaction and BMI for the IL1B × IL1RN interactions were significant for dominant model (p = 0.02) and codominant model (p = 0.03). The same SNP-SNP interaction (IL1B × IL1RN) was associated also with fat % for codominant (p = 0.01) and recessive (p = 0.002) models.ConclusionsThis study further confirmed that IL-1 family genes are involved in genetic background of obesity. It has been shown that interaction IL1B × IL1RN was associated with both BMI and fat % with rare T allele protecting form higher values. Thus, even if certain polymorphisms in single genes of IL-1 family cannot be defined as related to obesity in examined population, the genetic interrelationships should be analyzed.

【 授权许可】

CC BY