Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer’s disease

Aging Cell

Fabio Contu¹  Sabine Mai¹  Il‐Seon Park²  Md Golam Sharoar³  Riqiang Yan³  Tetiana Shcholok⁴  Eftekhar Eftekharpour⁴  Md Imamul Islam⁴  Pandian Nagakannan⁴  Marc R. Del Bigio⁵  Jun‐Feng Wang⁶  Benedict C Albensi⁷ 

[1] Cell Biology, Research Institute of Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada;Department of Cellular and Molecular Medicine, Chosun University, Gwangju, South Korea;Department of Neuroscience, University of Connecticut Health, Farmington, Connecticut, USA;Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada;Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada;Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada;Department of Pathology, Shared Health Manitoba, University of Manitoba, Winnipeg, MB, Canada;Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada;Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada;Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada;St Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB, Canada;Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida, USA;

关键词: acetylation;    amyloid beta;    chromatin;    histone;    lysosomal membrane permeabilization;    methylation;    nuclear lamina;    super‐resolution microscopy;   

DOI  :  10.1111/acel.13531

来源: Wiley

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