Soluble TREM‐1, as a new ligand for the membrane receptor Robo2, promotes hepatic stellate cells activation and liver fibrosis

Journal of Cellular and Molecular Medicine

Linping Shi¹  Shuling Wang²  Huiqing Jiang²  Hongqun Liu²  Xiaoyu Jiang²  Xue Zhou²  Yijun Wang²  Xiaoli Xie²  Ting Liu²  Jiuna Zhang²  Yongjuan Wang²  Ruolin Cui²  Shujia Chen³  Shengbin Qi⁴  Shengxiong Chen⁵  Shiying Dou⁶ 

[1] Department of Gastroenterology, Hebei General Hospital, Shijiazhuang, Hebei, China;Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, Shijiazhuang, Hebei, China;Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Hebei Clinical Research Center for Digestive Diseases, Shijiazhuang, Hebei, China;Department of Gastroenterology, Shijiazhuang People’s Hospital, Shijiazhuang, Hebei, China;Department of General Surgery, Shijiazhuang People’s Hospital, Shijiazhuang, Hebei, China;Department of Hepatobiliary Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China;Department of infectious diseases, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China;

关键词: hepatic stellate cell;    ligand;    liver fibrosis;    pro‐inflammatory factor;    receptor;    roundabout guidance receptor 2 (Robo2);    soluble triggering receptor expressed on myeloid cells‐1 (sTREM‐1);   

DOI  :  10.1111/jcmm.17033

来源: Wiley

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