TGF‐β/Smad and JAK/STAT pathways are involved in the anti‐fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis

Journal of Cellular and Molecular Medicine

Xiaoming Fan¹  Jianye Wu²  Jingjing Li²  Shizan Xu³  Chuanyong Guo⁴  Weiqi Dai⁵  Jiao Feng⁶  Kan Chen⁶  Liwei Wu⁶  Jie Ji⁶  Jiaojiao Chen⁷  Jie Zhang⁷  Qiang Yu⁷  Yuting Zhou⁷  Yuqing Mao⁸  Fan Wang⁹ 

[1] Department of Gastroenterology, Jinshan Hospital of Fudan University, Shanghai, China;Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai, China;Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai, China;Department of Gastroenterology, Jinshan Hospital of Fudan University, Shanghai, China;Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China;Shanghai Tenth Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai, China;Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai, China;Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China;Department of Gastroenterology, Putuo People's Hospital, Tongji University School of Medicine, Shanghai, China;Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China;Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China;Shanghai Institute of Liver Diseases, Zhongshan Hospital of Fudan University, Shanghai, China;Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China;Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China;Shanghai Tenth Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai, China;Department of Gerontology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

关键词: autophagy;    JAK2/STAT3;    liver fibrosis;    propylene glycol alginate sodium sulphate;    TGF‐β1/Smad2/3;   

DOI  :  10.1111/jcmm.15175

来源: Wiley

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