Phenotype correlations reveal the relationships of physiological systems underlying human ageing

Aging Cell

Zuyun Liu¹  Xiaoyan Jiang²  Qi Song³  Xi Wang³  Meng Hao³  Zixin Hu³  Xiaofeng Wang⁴  Hui Zhang⁴  Jiucun Wang⁵  Yi Li⁵  Li Jin⁶ 

[1] Center for Clinical Big Data and Analytics, Second Affiliated Hospital and Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China;Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine, Shanghai, China;State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China;State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China;National Clinical Research Center for Ageing and Medicine, Huashan Hospital, Fudan University, Shanghai, China;State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China;Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058), Chinese Academy of Medical Sciences, Beijing, China;State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China;Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058), Chinese Academy of Medical Sciences, Beijing, China;International Human Phenome Institutes, Shanghai, China;

关键词: composite phenotype analysis;    functional ageing;    human ageing;    phenotypic ageing;    physiological systems;   

DOI  :  10.1111/acel.13519

来源: Wiley

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