Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens

Molecular Systems Biology

Andrew R Leach¹  Aldo Segura‐Cabrera¹  Claire Crafter²  Ben Sidders²  James T Lynch²  Stephen Fawell³  James Morris⁴  Ermira Lleshi⁴  Fiona M Behan⁴  Clare Pacini⁴  Howard Lightfoot⁴  Frances Thomas⁴  James Hall⁴  Patricia Jaaks⁴  Donny van der Meer⁴  Iman Mali⁴  Gabriele Picco⁴  Alexandra Beck⁴  Laura Richardson⁴  Elizabeth A Coker⁴  Charlotte Tolley⁴  Andrew Barthorpe⁴  Tatiana Mironenko⁴  Wanjuan Yang⁴  Mathew J Garnett⁴  Caitlin Hall⁴  Emanuel Gonçalves⁴  Francesco Iorio⁵ 

[1] European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK;Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK;Research and Early Development, Oncology R&D, AstraZeneca, Waltham, MA, USA;Wellcome Sanger Institute, Hinxton, UK;Wellcome Sanger Institute, Hinxton, UK;Human Technopole, Milano, Italy;

关键词: CRISPR;    drug mechanism‐of‐action;    protein networks;   

DOI  :  10.15252/msb.20199405

来源: Wiley

【 授权许可】

CC BY