Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

Journal of Cellular and Molecular Medicine

Jonathan D. Rohrer¹  Huw R. Morris²  Noemi Esteras²  Andrey Y. Abramov²  Núria Setó‐Salvia³  Rohan de Silva³  Eduardo de Pablo‐Fernandez⁴  Thomas T. Warner⁴  Charles Arber⁵  Selina Wray⁵  James M. Polke⁶  Christina E. Toomey⁷  Rickie Patani⁸ 

[1] Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK;Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK;Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK;Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK;Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK;Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London, UK;Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK;Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK;Neurogenetics Laboratory, The National Hospital for Neurology and Neurosurgery, London, UK;Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK;Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK;The Francis Crick Institute, London, UK;

关键词: 4R‐tau;    astrocytes;    frontotemporal dementia;    frontotemporal lobar degeneration;    pluripotent stem cells;    tauopathies;   

DOI  :  10.1111/jcmm.17136

来源: Wiley

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