Adiponectin alleviated Alzheimer‐like pathologies via autophagy‐lysosomal activation

Aging Cell

Zhi‐Jian Yu¹  Shujin Wang²  Xifei Yang³  Lulin Nie³  Jianjun Liu³  Xiao Chen³  Kaiqin Zhang⁴  Jia Xu⁵  Tahir Ali⁶  Weifen Li⁶  Zizhen Liu⁶  Shupeng Li⁷  Kaiwu He⁸ 

[1] Department of Infectious Diseases and Shenzhen key laboratory for endogenous infections, the 6th Affiliated Hospital of Shenzhen University Health Science Center, Nanshan District, Shenzhen, China;Department of Neurology, the First People’s Hospital of Zibo Affiliated to Weifang Medical College, Zibo, China;Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China;Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China;College of Public Health, University of South China, Hengyang, China;Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China;Department of Pathophysiology, Guangzhou Medical University, Guangzhou, China;State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China;State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China;Campbell Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada;Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada;State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China;Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China;

关键词: adiponectin;    autophagy‐lysosomal pathway;    cognitive impairments;    dementia;    neuroinflammation;   

DOI  :  10.1111/acel.13514

来源: Wiley

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