Notoginsenoside R1 attenuates oxidative stress‐induced osteoblast dysfunction through JNK signalling pathway

Journal of Cellular and Molecular Medicine

Tim Forouzanfar¹  Gang Wu²  Shengbin Huang³  Xumin Li⁴  Yinghui Ji⁵  Qihao Yu⁶  Xiaorong Zhang⁷  Richard T. Jaspers⁸  Haiyan Lin⁹  Dongyun Wang^1,10 

[1] Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam (VUA), Amsterdam Movement Science, Amsterdam, The Netherlands;Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam (VUA), Amsterdam Movement Science, Amsterdam, The Netherlands;Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), Amsterdam, The Netherlands;Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), Amsterdam, The Netherlands;Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam (VUA), Amsterdam Movement Science, Amsterdam, The Netherlands;Laboratory for Myology, Amsterdam Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam (VUA), Amsterdam, The Netherlands;Department of Prosthodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Laboratory for Myology, Amsterdam Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam (VUA), Amsterdam, The Netherlands;Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Laboratory for Myology, Amsterdam Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam (VUA), Amsterdam, The Netherlands;Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, PR China;Laboratory for Myology, Amsterdam Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam (VUA), Amsterdam, The Netherlands;Savaid Stomatology School, Hangzhou Medical College, Hangzhou, PR China;Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, PR China;

关键词: dysfunction;    JNK;    mitochondria;    NGR1;    osteoblast;    oxidative stress;   

DOI  :  10.1111/jcmm.17054

来源: Wiley

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